Int J Cardiol:血尿酸持续较高,增加心梗风险!开滦研究7.1万余人分析

2020-04-29 朱朱 中国循环杂志

高尿酸是很多中老年人体检结果中最常见的异常指标之一。作为一个代谢因素,高尿酸血症在心肌梗死的发生过程中挥发怎样的作用,至今仍存在争议。

高尿酸是很多中老年人体检结果中最常见的异常指标之一。作为一个代谢因素,高尿酸血症在心肌梗死的发生过程中挥发怎样的作用,至今仍存在争议。

近期,首都医科大学公共卫生学院罗艳侠等联合北京天坛医院、河北开滦医院学者开展的一项大规模研究提示,只有血尿酸水平一直保持在较高的水平时,心肌梗死风险才会增加。

在较长时间内,血尿酸水平升高或降低,或者仅是最开始时升高,均与心肌梗死风险无关。

该研究一共纳入7.1万余名基线无心肌梗死的成年人,其平均年龄为50.9岁。根据基线和第二次随访时的血尿酸水平,这些人被分为血尿酸维持在较低水平、升高、降低以及维持在较高水平四类。

平均随访8.96年期间,837人发生心肌梗死。

校正潜在混淆因素后,与血尿酸水平始终保持为较低水平的人相比,只有血尿酸水平一直处于较高水平的人心肌梗死风险增加,增幅为42%。

与基线血尿酸水平正常的人相比,基线血尿酸水平升高的人发生心肌梗死的风险并未增加。这在不同年龄、性别、估算肾小球滤过率以及有或无高血压、糖尿病的人中均得到了验证。

进一步分析显示,稳定高尿酸血症与心肌梗死之间的关系,在一定程度上(14.14%)与高血压有关。

原始出处:Tian X, Zuo Y, Chen S, et al. Associations Between Changes in Serum Uric Acid and the Risk of Myocardial Infarction. Int J Cardiol. 2020 Apr 22

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    2020-04-30 quxin068

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