J Clin Periodontol:种植体周围炎的两种非手术治疗方式的短期比较——双因素随机对照试验的临床和微生物学结果

2021-07-06 MedSci原创 MedSci原创

氨基酸甘氨酸的研磨粉已被证实可以有效地清洁被污染的种植体表面。近期一些新的研究显示,一种含有羟基苯磺酸和羟基甲氧基苯酸和硫酸(HybenX)的浓缩水混合物的口腔组织去污剂可较洁治和刮治更好的减少慢性牙

氨基酸甘氨酸的研磨粉已被证实可以有效地清洁被污染的种植体表面。近期一些新的研究显示,一种含有羟基苯磺酸和羟基甲氧基苯酸和硫酸(HybenX)的浓缩水混合物的口腔组织去污剂可较洁治和刮治更好的减少慢性牙周炎患者的临床、微生物和炎症介质,但尚未在随机试验中得到检验。为此,一项随机临床试验比较了两种不同疗法(氨基酸甘氨酸研磨粉和一种干燥剂材料)及其组合在非手术治疗种植体周围炎中的疗效,研究结果已发表于 J Clin Periodontol。

这是一项检查员盲法的随机临床试验,采用2因素设计,分为四组:(a) 单纯的非手术清创(C);(b) 非手术清创和干燥剂材料(H);(c) 非手术清创和甘氨酸粉(G);以及(d) 非手术清创、干燥剂材料和甘氨酸粉(HG);随访6个月。

 

结果,共随机分配64名种植体周围炎患者,每组16名患者。6个月后,G组有两个种植体失败。干燥剂材料治疗组患者的平均牙周袋深度减少较多(估计差异:0.5 mm;95% CI从0.1~0.9 mm,p = .0229),而使用甘氨酸粉末治疗组患者没有差异(估计差异:0.1毫米;95% CI从-0.3~0.5 mm,p = .7333)。接受甘氨酸粉治疗的患者在干预期间的疼痛VAS和一周后的疼痛VAS更高(分别为p = .0056和p = .0339)。成功标准和其他变量没有显示出组间差异。

综上,在这项为期6个月的随访研究中,使用干燥剂材料的患者牙周袋减小更明显。使用甘氨酸的患者疼痛感更强。所有的干预措施成功率都低。

 

原始出处:

 

Mauro Merli, et al., Short-term comparison of two non-surgical treatment modalities of peri-implantitis: Clinical and microbiological outcomes in a two-factorial randomized controlled trial. J Clin Periodontol. 2020 Oct;47(10):1268-1280. doi: 10.1111/jcpe.13345.  

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    2022-03-14 feather89
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[GetPortalCommentsPageByObjectIdResponse(id=1688207, encodeId=4015168820ee7, content=<a href='/topic/show?id=c7a75068505' target=_blank style='color:#2F92EE;'>#微生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50685, encryptionId=c7a75068505, topicName=微生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27b028484196, createdName=1249883fm21暂无昵称, createdTime=Tue Dec 21 13:01:45 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975807, encodeId=73ab19e58079f, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Jan 26 06:01:45 CST 2022, time=2022-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729020, encodeId=e7f31e29020b9, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Mar 14 05:01:45 CST 2022, time=2022-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825297, encodeId=783c182529e00, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344004, encodeId=3789134400483, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Jul 08 10:01:45 CST 2021, time=2021-07-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1688207, encodeId=4015168820ee7, content=<a href='/topic/show?id=c7a75068505' target=_blank style='color:#2F92EE;'>#微生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50685, encryptionId=c7a75068505, topicName=微生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27b028484196, createdName=1249883fm21暂无昵称, createdTime=Tue Dec 21 13:01:45 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975807, encodeId=73ab19e58079f, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Jan 11 19:01:45 CST 2022, time=2022-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702201, encodeId=cad41e0220124, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sat Sep 04 17:01:45 CST 2021, time=2021-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775568, encodeId=c66e1e7556855, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Tue Sep 07 02:01:45 CST 2021, time=2021-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987301, encodeId=0350198e301a3, content=<a href='/topic/show?id=bac5466546c' target=_blank style='color:#2F92EE;'>#对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46654, encryptionId=bac5466546c, topicName=对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Mon Jun 20 05:01:45 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290772, encodeId=5f431290e7284, content=<a href='/topic/show?id=e86454454ea' target=_blank style='color:#2F92EE;'>#手术治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54454, encryptionId=e86454454ea, topicName=手术治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Thu Jul 08 10:01:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296266, encodeId=26fa129626653, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Thu Jul 08 10:01:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344004, encodeId=3789134400483, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Jul 08 10:01:45 CST 2021, time=2021-07-08, status=1, ipAttribution=)]
    2021-09-04 huangdf
  6. [GetPortalCommentsPageByObjectIdResponse(id=1688207, encodeId=4015168820ee7, content=<a href='/topic/show?id=c7a75068505' target=_blank style='color:#2F92EE;'>#微生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50685, encryptionId=c7a75068505, topicName=微生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27b028484196, createdName=1249883fm21暂无昵称, createdTime=Tue Dec 21 13:01:45 CST 2021, time=2021-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975807, encodeId=73ab19e58079f, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344004, encodeId=3789134400483, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Jul 08 10:01:45 CST 2021, time=2021-07-08, status=1, ipAttribution=)]
    2021-09-07 amyloid
  7. 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2019 丹麦国家临床指南:腰椎管狭窄患者的手术和非手术治疗

丹麦腰椎管狭窄患者的手术和非手术治疗国家临床指南主要总结了当前关于腰椎管狭窄患者的手术和非手术治疗的指导建议,其中7条建议基于随机对照试验,3条建议是基于专家共识。指南建议对有症状的腰椎管狭窄症患者进行手术减压治疗。

J Rheumatol:在全膝关节置换术前使用推荐的非手术性骨关节炎治疗

在对计划接受TKA的膝关节OA患者进行的大型横断面分析中,40%的患者未接受核心推荐的非手术治疗。

2019 OARSI指南:膝关节、髋关节和多关节骨关节炎的非手术治疗

2019年7月,国际骨关节炎研究协会(OARSI)发布了膝关节、髋关节和多关节骨关节炎的非手术治疗指南,本文是对前期OARSI关于 OARSI患者治疗指南的更新和扩展,针对这些关节炎疾病患者提供了全面的以患者为中心的治疗方案。

Photodiagnosis Photodyn Ther:基于吲哚菁绿的抗菌光动力疗法治疗慢性牙周炎的效果

本研究旨在评估基于吲哚菁绿(ICG)的抗菌光动力疗法(aPDT)在慢性牙周炎非手术治疗中的作用。

2020 共识声明建议:甲状腺良性结节非手术以及非放射性碘消融治疗

甲状腺结节和囊肿比较常见,手术治疗是有症状甲状腺结节,疑似恶性肿瘤结节和甲状腺癌的标准治疗方法,放射性碘治疗主要用于具有自主功能的结节。本文主要针对甲状腺良性结节非手术以及非放射性碘消融治疗提供指导建议。

J Periodontal Res:Netrin-1及其受体Unc5b作为牙周病标记物

Netrin-1通过其受体UNC5b调节炎症反应,并在骨破坏性疾病中发挥作用。本研究的目的是评估Netrin-1和Unc5b在牙周健康和疾病中的水平。