Clin Nutrition:维生素D缺乏与脑组织健康程度存在关联

2021-01-10 MedSci原创 MedSci原创

有文献已经证实,维生素D缺乏与痴呆症的风险增加有关。

      有文献已经证实,维生素D缺乏与痴呆症的风险增加有关。为了验证这一证据并明确维生素D是否确实可以在早期预防神经退行性变中起作用,研究人员进行可一项流调研究,他们调查无痴呆症人群中维生素D状况与脑组织量,海马体量,白质完整性和脑小血管疾病(CSVD)标记的关系,并进行相应的分析。

 

 

      在这项横断面分析中,从2006年至2009年,研究人员收集了2716名无痴呆症参与者接受了血清25(OH)D浓度评估和脑磁共振成像(MRI)扫描。主要观察结果包括脑组织体积(总量,白质,灰质和海马体积),白质完整性(分数各向异性(FA)和平均扩散率(MD))和CSVD标记(白质超强度(WMH)体积,内腔和微出血情况)。使用多变量线性和逻辑回归模型评估了维生素D状态与这些大脑测量值之间的关联,并根据生活方式和其他疾病风险因素进行了调整。

 

       结果显示与足够的维生素D状态(≥50nmol / L)相比,维生素D缺乏症(25(OH)D <30 nmol / L)与较小的脑组织体积,较小的白质体积和较小的海马体积独立相关。 但是,维生素D的状态与灰质量,白质完整性或CSVD标记物无关。

 

 

      研究人员最后说道:在这个无痴呆症的人群中,维生素D缺乏与较小的脑组织体积和海马体积有关。但是仍需要进一步的研究阐明维生素D在神经变性中的作用。

 

 

原始出处:

Pauline H. Croll. Et al. Associations of vitamin D deficiency with MRI markers of brain health in a community sample. Clinical Nutrition.2021.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1661616, encodeId=f7f0166161603, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Aug 06 20:33:29 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915849, encodeId=c08191584999, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:22:08 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592055, encodeId=bf1e1592055bb, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Tue Jan 12 05:33:29 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915329, encodeId=b36691532934, content=脑组织健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jan 10 19:04:09 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915318, encodeId=10df9153188f, content=平台很好,多多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b55451559, createdName=理想15279388401, createdTime=Sun Jan 10 18:20:39 CST 2021, time=2021-01-10, status=1, ipAttribution=)]
    2021-01-12 ms5000001559080486

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1661616, encodeId=f7f0166161603, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Aug 06 20:33:29 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915849, encodeId=c08191584999, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:22:08 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592055, encodeId=bf1e1592055bb, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Tue Jan 12 05:33:29 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915329, encodeId=b36691532934, content=脑组织健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jan 10 19:04:09 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915318, encodeId=10df9153188f, content=平台很好,多多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b55451559, createdName=理想15279388401, createdTime=Sun Jan 10 18:20:39 CST 2021, time=2021-01-10, status=1, ipAttribution=)]
    2021-01-12 yahu
  4. [GetPortalCommentsPageByObjectIdResponse(id=1661616, encodeId=f7f0166161603, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Aug 06 20:33:29 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915849, encodeId=c08191584999, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:22:08 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592055, encodeId=bf1e1592055bb, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Tue Jan 12 05:33:29 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915329, encodeId=b36691532934, content=脑组织健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jan 10 19:04:09 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915318, encodeId=10df9153188f, content=平台很好,多多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b55451559, createdName=理想15279388401, createdTime=Sun Jan 10 18:20:39 CST 2021, time=2021-01-10, status=1, ipAttribution=)]
    2021-01-10 oo902

    脑组织健康

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661616, encodeId=f7f0166161603, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Aug 06 20:33:29 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915849, encodeId=c08191584999, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89175451903, createdName=ms5000001559080486, createdTime=Tue Jan 12 11:22:08 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592055, encodeId=bf1e1592055bb, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Tue Jan 12 05:33:29 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915329, encodeId=b36691532934, content=脑组织健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Jan 10 19:04:09 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915318, encodeId=10df9153188f, content=平台很好,多多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b55451559, createdName=理想15279388401, createdTime=Sun Jan 10 18:20:39 CST 2021, time=2021-01-10, status=1, ipAttribution=)]
    2021-01-10 理想15279388401

    平台很好,多多学习

    0

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