Cell Death Dis:口腔扁平苔藓的守护因子:MicroRNA-26a/b

2020-02-08 QQY MedSci原创

口腔扁平苔藓(OLP)是一种以角质形成细胞凋亡及炎症反应为特征的口腔上皮疾病。 目前OLP的发病机制仍未完全明确。研究人员发现与健康对照相比,OLP患者的口腔黏膜活检、血清及唾液中的miR-26a/b表达水平严重下调。此外,研究人员还在miR-26a/b基因的启动子区域中发现了维生素D受体(VDR)的结合位点,并证实miR-26a/b的诱导表达是VDR依赖性的。在维生素D缺乏或VDR敲除小鼠的口腔

口腔扁平苔藓(OLP)是一种以角质形成细胞凋亡及炎症反应为特征的口腔上皮疾病。 目前OLP的发病机制仍未完全明确。

研究人员发现与健康对照相比,OLP患者的口腔黏膜活检、血清及唾液中的miR-26a/b表达水平严重下调。此外,研究人员还在miR-26a/b基因的启动子区域中发现了维生素D受体(VDR)的结合位点,并证实miR-26a/b的诱导表达是VDR依赖性的。

维生素D缺乏或VDR敲除小鼠的口腔上皮中也检测到miR-26a/b的表达下调。而miR-26a/b抑制剂可以增强口腔角质形成细胞的凋亡以及Th1细胞相关因子的产生,而miR-26a/b类似物则具有保护作用。

在机制上,研究人员分析了miRNA的靶基因,并确认miR-26a/b可以通过直接靶向促进细胞凋亡的蛋白激酶Cδ(PKCδ)来阻断细胞凋亡。同时,miR-26a/b通过靶向CD38抑制Th1细胞相关因子的分泌。与OLP患者样品中miR-26a/b表达水平下调一致,样品中的PKCδ及CD38表达水平升高。

综上所述,本研究表明,维生素D/VDR诱导的miR-26a/b表达可以通过抑制角质形成细胞凋亡及抑制口腔炎症反应在OLP中发挥保护作用。

原始出处:

Du et al. MicroRNA-26a/b have protective roles in oral lichen planus.Cell Death and Disease (2020) 11:15

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    2020-12-24 维他命
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582195, encodeId=d2651582195d9, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Feb 10 08:51:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623176, encodeId=250516231e6d1, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Feb 10 08:51:00 CST 2020, time=2020-02-10, status=1, ipAttribution=)]
    2020-12-16 xjy02
  5. 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  6. 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createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Feb 10 08:51:00 CST 2020, time=2020-02-10, status=1, ipAttribution=)]
    2020-02-10 zhouqu_8
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582195, encodeId=d2651582195d9, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Feb 10 08:51:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623176, encodeId=250516231e6d1, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Feb 10 08:51:00 CST 2020, time=2020-02-10, status=1, ipAttribution=)]
    2020-02-10 cy0328
  8. 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  9. 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