GUT:炎症性肠病人群结肠镜后结直肠癌风险研究

2018-12-18 zhangfan MedSci原创

研究认为,炎症性肠病患者结肠镜检查后结肠癌发病风险较高,上述人群应适当增加复查频率

结肠镜直肠癌(PCCRC)的发生率被认为是结肠镜检查质量的重要指标,对对于炎症性肠病患者(IBD),IBD病情对PCCRC的影响尚未被阐明。

2001-10年间,研究人员在瑞典开展一项基于人口的结肠镜队列研究,依据患者是否患有溃疡性结肠炎克罗恩病,考察参与者结肠镜检查36个月内的结肠癌发病率以及发病时间(0-6个月vs6-36个月)。采用Poisson回归分析PCCRC与IBD(CD和UC)诊断、年龄、性别、病灶位置、时间和并发症的关系。

270918名参与者接受348232次结肠镜检查。14597名CD患者接受27123次结肠镜检查,26512名UC患者进行了51572次检查。研究发现,非IBD组发生13317例CRC事件,UC组发生281例,CD组发生133例。CD组PCCRC率为28.3%,UC组为41.0%,相对于非IBD人群。CD以及UC人群的CRC风险分别为3.82和5.89倍。CD患者以及年轻UC患者的直肠癌风险最高。

研究认为,炎症性肠病患者结肠镜检查后结肠癌发病风险较高,上述人群应适当增加复查频率。

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    2019-04-17 sjq027
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    2018-12-20 zhouqu_8
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    2018-12-18 lietome15

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0