Alzheimers Dementia:痴呆者,更容易患新冠,且和年龄无关

2021-06-16 Freeman MedSci原创

痴呆者,更容易患新冠,且和年龄无关

COVID-19大流行已经席卷全球1年多,老年人被发现特别容易受到COVID-19的影响:例如,在英国,90%与COVID有关的死亡是在60岁以上的人群中,而80岁或以上的人被发现比50至59岁的人风险高20倍。

除了其他慢性并发症,包括血管和呼吸系统疾病、高血压、糖尿病、肥胖症和癌症,痴呆症已被确定为COVID-19的一个风险因素。然而,这种关联的原因仍然不清楚。有人认为,痴呆症患者的COVID-19患病率增加,至少部分原因可能是由于生活在护理或养老院,依赖外部护理人员,和/或缺乏独立性和保持卫生/预防保健措施的能力,所有这些都会增加感染的风险。

此外,年龄是痴呆症(尤其是阿尔茨海默病[AD])发展的主要风险因素,这使得COVID-19与全因痴呆症或AD之间的关联有可能被解释为痴呆症患者平均年龄大于无痴呆症患者。最后,目前还不清楚AD和帕金森病(PD)这两种在老年人中最流行的神经退行性疾病是否与COVID-19感染或其结果特别相关,或者COVID-19与全因痴呆之间的关联是否来自其他形式的痴呆(非AD、非PD)的贡献。


藉此,巴西圣保罗大学的Ana C. Tahira等人,利用应该UKB数据,在12,863名接受COVID-19检测的英国老人探究痴呆和COVID之间的关系,其中>65岁(1814人≥80岁),1167人COVID阳性。

风险因素:包括全因痴呆,特别是AD和PD,与COVID-19阳性、严重程度(住院)和死亡的关系。为了说明年龄是一个风险因素,我们将我们的队列分为三组,包括66至74岁、75至79岁和80岁及以上的人。

结果表明,所有原因的痴呆,特别是AD,与较高的COVID-19阳性诊断和住院风险有关,与年龄无关,甚至在80岁及以上的人中,也是住院病人严重程度和死亡的有力风险因素。


他们发现,全因痴呆、阿尔茨海默氏病(AD)和帕金森病与COVID-19阳性诊断有关,而全因痴呆和阿尔茨海默病 在≥80岁的人中仍有关联。

全因痴呆、AD或PD都不是整体住院的风险因素。痴呆、AD或PD不是整体住院的风险因素,但增加了COVID-19患者的住院风险。

全因性痴呆和AD增加了COVID-19的相关的死亡,而全因性痴呆与≥80岁患者的死亡增加有独特的关系。

这个超过万人的研究的重要意义在于发现了,全因性痴呆和AD是COVID19严重程度和死亡风险因素,而且这种关联和年龄无关

原文出处:

Tahira AC, Verjovski-Almeida S, Ferreira ST. Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients. Alzheimers Dement. 2021 Apr 21. doi: 10.1002/alz.12352. Epub ahead of print. PMID: 33881211.

 
 
 
 

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    2021-10-06 anminleiryan
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    2021-06-16 学医无涯

    新冠也看人下毒

    0

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    2021-06-13 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-06-13 junJUN

    老年人痴呆何药可用??

    0

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