Clin Nutr:重症监护室入院时的营养风险和危重症幸存者的预后

2021-06-22 MedSci原创 MedSci原创

进ICU时更高的营养风险与危重疾病幸存者的残疾风险有关

危重病后预后不良的风险因素尚未完全明确。虽然营养风险与危重患者的死亡率有关,但其与危重疾病幸存者的残疾、认知和健康相关生活质量的关系尚不清楚。

本研究旨在确定进ICU时的营养风险是否与随访3个月和12个月内的残疾、认知障碍和较差的HRQOL是否相关。

招募了在内科和外科ICU接受治疗的年满18岁的有呼吸衰竭或休克的成人患者。在患者进ICU时采用改良的危重病营养风险 (mNUTRIC) 评分(范围 0-9)评估患者的营养风险,采用相应的方法评估mNUTRIC 评分与出院目的、日常生活基本活动 (ADL) 残疾、工具性 ADL、整体认知功能、执行功能和健康相关生活质量之间的关联,并根据性别、教育、BMI、基础虚弱、残疾、认知、疾病严重程度等因素进行校正。

从ICU供招募了821位患者,其中636位活着出院。研究人员评估了3个月时535位幸存者中的448位(84%)和12个月时476位幸存者中的382位(80%)患者的预后。

进ICU时的mNUTRIC评分与顺利出院的相关性

mNUTRIC分数越高预测出院的可能性越大(OR 2.0, 95% CI: 1.6-2.6; P<0.01)。较高的mNUTRIC分数还与在3个月时日常生活的基本活动中出现更严重的残疾的趋势相关(IRR 1.3, 95% CI 1.0-1.7),但无显著性(p=0.09),而且在12个月时未再观察到此相关性。mNUTRIC评分与其他评估方法(FAQ、RBANS和Trails B评分)无相关性。mNUTRIC评分还与SF-36(评估健康相关生活质量)身心成分量表评分不一致。

总体上,进ICU时更高的营养风险与危重疾病幸存者的残疾风险有关。未来的研究应评估对高营养风险人群进行干预是否可加速其康复。

原始出处:

Mart Matthew F,Girard Timothy D,Thompson Jennifer L et al. Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness.[J] .Clin Nutr, 2021, 40: 3868-3874. https://doi.org/10.1016/j.clnu.2021.05.005

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