Heart:对比增强CT评估主动脉瓣狭窄的意义

2021-02-01 MedSci原创 MedSci原创

对比增强CT评估主动脉瓣钙化和非钙化体积的变化与主动脉瓣狭窄程度相关,当纤维化是导致瓣膜阻塞的重要因素时,其评估效能优于非对比CT。

非对比CT主动脉瓣钙化评分忽略了瓣膜纤维化在主动脉瓣狭窄中的意义。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在使用对比增强CT评估主动脉瓣钙化和非钙化疾病。

这是对164例主动脉瓣狭窄患者(中位年龄为71岁(IQR为66-77岁),男性占78%)进行的事后分析(41例轻度,89例中度,34例重度主动脉瓣狭窄;7%二尖瓣狭窄),他们接受了超声心动图检查和对比增强CT作为影像学检查的一部分。研究人员针对血液放射密度校准的Hounsfield单位阈值对钙化和非钙化(纤维化)的瓣膜组织体积进行定量,并确定瓣环面积。纤维钙化比值用于评估瓣膜纤维化和钙化的相对程度。研究人员将纤维钙化体积(非钙化和钙化体积的总和)与主动脉瓣峰值速度进行比较,并在一个亚组中比较了组织学和瓣膜重量。

对比增强的CT钙体积与CT钙评分(r=0.80,p<0.001)和主动脉射流峰值速度(r=0.55,p<0.001)相关。纤维钙化比值随主动脉狭窄严重程度的增加而降低(轻度:1.29(0.98-2.38),中度:0.87(1.48-1.72),重度:0.47(0.33-0.78),p<0.001),而纤维化钙化量增加(轻度:109(75-150),中度:191(117-253),重度:274(213-344)mm3/ m2)。纤维钙化体积与离体瓣膜重量相关(r=0.72,p<0.001)。与Agatston评分相比,纤维钙化体积证实与峰值主动脉射流速度具有更好的相关性(分别为r=0.59和r=0.67),特别是在女性患者中(分别为r=0.38和r=0.72)。

由此可见,对比增强CT评估主动脉瓣钙化和非钙化体积的变化与主动脉瓣狭窄程度相关,当纤维化是导致瓣膜阻塞的重要因素时,其评估效能优于非对比CT

原始出处:

Timothy RG Cartlidge.et al.Contrast-enhanced computed tomography assessment of aortic stenosis.heart.2021.https://heart.bmj.com/content/early/2021/01/28/heartjnl-2020-318556

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    2021-02-03 Aidy

    对比增强CT评估主动脉瓣钙化和非钙化体积的变化与主动脉瓣狭窄程度相关,当纤维化是导致瓣膜阻塞的重要因素时,其评估效能优于非对比CT。

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1994279, encodeId=f3c919942e93a, content=<a href='/topic/show?id=db8b46645ee' target=_blank style='color:#2F92EE;'>#对比增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46645, encryptionId=db8b46645ee, topicName=对比增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Mon Jul 19 16:09:06 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987062, encodeId=17e4198e06241, content=<a href='/topic/show?id=a498422e7e6' target=_blank style='color:#2F92EE;'>#增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42277, encryptionId=a498422e7e6, topicName=增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Nov 14 03:09:06 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=922613, encodeId=f7ab92261303, content=对比增强CT评估主动脉瓣钙化和非钙化体积的变化与主动脉瓣狭窄程度相关,当纤维化是导致瓣膜阻塞的重要因素时,其评估效能优于非对比CT。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8585442638, createdName=Aidy, createdTime=Wed Feb 03 23:01:26 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332781, encodeId=4e6b1332e813c, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357653, encodeId=6e70135e65308, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415726, encodeId=f0b91415e26ed, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563411, encodeId=e6791563411f0, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=)]
    2021-02-03 柳叶一刀
  6. [GetPortalCommentsPageByObjectIdResponse(id=1994279, encodeId=f3c919942e93a, content=<a href='/topic/show?id=db8b46645ee' target=_blank style='color:#2F92EE;'>#对比增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46645, encryptionId=db8b46645ee, topicName=对比增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Mon Jul 19 16:09:06 CST 2021, time=2021-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987062, encodeId=17e4198e06241, content=<a href='/topic/show?id=a498422e7e6' target=_blank style='color:#2F92EE;'>#增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42277, encryptionId=a498422e7e6, topicName=增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Nov 14 03:09:06 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=922613, encodeId=f7ab92261303, content=对比增强CT评估主动脉瓣钙化和非钙化体积的变化与主动脉瓣狭窄程度相关,当纤维化是导致瓣膜阻塞的重要因素时,其评估效能优于非对比CT。, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8585442638, createdName=Aidy, createdTime=Wed Feb 03 23:01:26 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332781, encodeId=4e6b1332e813c, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357653, encodeId=6e70135e65308, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415726, encodeId=f0b91415e26ed, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563411, encodeId=e6791563411f0, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Feb 03 11:09:06 CST 2021, time=2021-02-03, status=1, ipAttribution=)]
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    2021-02-03 slcumt

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