Clin Gastroenterology H:高摄入蔬菜或多不饱和脂肪与降低肝细胞癌的风险有关

2020-11-07 MedSci原创 MedSci原创

新鲜蔬菜和水果中,都含有多种维生素和各种微量元素,它们是人体中不可缺少的物质.如长期吃菜过少,往往会使人因缺乏维生素引起某些疾病,甚至容易得癌症。

背景与目标

新鲜蔬菜和水果中,都含有多种维生素和各种微量元素,它们是人体中不可缺少的物质.如长期吃菜过少,往往会使人因缺乏维生素引起某些疾病,甚至容易得癌症,因此,本项旨在探究总脂肪,特定饮食脂肪以及不同食物来源的脂肪与肝细胞癌(HCC)风险之间的联系。

 

方法

本项研究共分析了138483名参加护理健康数据库中的临床数据。经过验证的半定量食物频率问卷于1980年,1984年,1986年发送给NHS参与者,此后每4年发送一次;1986年和之后每4年从参与者中收集饮食信息。使用Cox比例风险回归估算多变量危险比(HRs)和95%CI。

 

 

结果

经过平均26.6年的随访时间,研究人员共记录了160例HCC事件的发生。尽管总脂肪摄入量与HCC之间无显着相关性,但植物脂肪的摄入降低了HCC的风险(最高四分位数与最低四分位数的HR为0.61; 95%CI为0.39-0.96; P= .02)。用等量的植物脂肪代替动物或乳制品脂肪具有较低的HCC风险(HR,0.79; 95%CI,0.65-0.97)。在脂肪亚型中,单不饱和脂肪酸和多不饱和脂肪酸,包括n-3(HR,0.63; 95%CI,0.41-0.96; P= .14)和n-6多不饱和脂肪酸(HR,0.54; 95%CI,0.34-0.86; P = .02)与HCC的发生风险呈负相关。单不饱和或多不饱和脂肪与饱和脂肪的比率较高与HCC风险呈负相关(P ≤.02)。此外,当用单不饱和或多不饱和脂肪代替饱和脂肪时,HR为0.77(95%CI,0.64-0.92)。

 

 

结论

本项研究发现摄入较高的植物脂肪和多不饱和脂肪与较低的HCC风险有关。用植物脂肪代替动物或乳制品脂肪,或用单不饱和或多不饱和脂肪代替饱和脂肪与降低HCC的风险有关。

 

 

原始出处:

Wanshui Yang. Et al. High Dietary Intake of Vegetable or Polyunsaturated Fats Is Associated With Reduced Risk of Hepatocellular Carcinoma. Clinical Gastroenterology and Hepatology.

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    2021-08-02 xjy02
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createdBy=0bed488, createdName=jktdtl, createdTime=Mon Apr 12 02:05:22 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979042, encodeId=5c8419e904245, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Sep 15 16:05:22 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073154, encodeId=09ae20e31549d, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 05 17:05:22 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712597, encodeId=6f651e1259777, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Mar 04 23:05:22 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897957, encodeId=6c0989e95719, content=摄入较高的植物脂肪和多不饱和脂肪与较低的HCC风险有关。用植物脂肪代替动物或乳制品脂肪,或用单不饱和或多不饱和脂肪代替饱和脂肪与降低HCC的风险有关。 多吃蔬菜,多吃不饱和脂肪酸 , beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Nov 09 14:22:19 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505125, encodeId=9130150512507, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Nov 09 02:05:22 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580013, encodeId=9b9f1580013fa, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Mon Nov 09 02:05:22 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897559, encodeId=cb8c89e55914, content=这个说的好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/430d27eddbd94420b194a13670107723/4a1c6e6f8d39496994128f96c372bf9b.jpg, createdBy=c7093956685, createdName=1393d772m33暂无昵称, createdTime=Sat Nov 07 12:33:01 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897550, encodeId=da1e89e5504c, content=多吃蔬菜水果, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sat Nov 07 11:57:25 CST 2020, time=2020-11-07, status=1, ipAttribution=)]
    2021-02-05 许安
  5. 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channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Nov 09 14:22:19 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505125, encodeId=9130150512507, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Nov 09 02:05:22 CST 2020, time=2020-11-09, status=1, ipAttribution=), 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createdTime=Sat Nov 07 12:33:01 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897550, encodeId=da1e89e5504c, content=多吃蔬菜水果, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sat Nov 07 11:57:25 CST 2020, time=2020-11-07, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1863523, encodeId=0b69186352351, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Aug 02 01:05:22 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065196, encodeId=bbbe20651968d, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 05 17:05:22 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712597, encodeId=6f651e1259777, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Mar 04 23:05:22 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897957, encodeId=6c0989e95719, content=摄入较高的植物脂肪和多不饱和脂肪与较低的HCC风险有关。用植物脂肪代替动物或乳制品脂肪,或用单不饱和或多不饱和脂肪代替饱和脂肪与降低HCC的风险有关。 多吃蔬菜,多吃不饱和脂肪酸 , beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Nov 09 14:22:19 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505125, encodeId=9130150512507, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Nov 09 02:05:22 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580013, encodeId=9b9f1580013fa, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Mon Nov 09 02:05:22 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897559, encodeId=cb8c89e55914, content=这个说的好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/430d27eddbd94420b194a13670107723/4a1c6e6f8d39496994128f96c372bf9b.jpg, createdBy=c7093956685, createdName=1393d772m33暂无昵称, createdTime=Sat Nov 07 12:33:01 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897550, encodeId=da1e89e5504c, content=多吃蔬菜水果, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sat Nov 07 11:57:25 CST 2020, time=2020-11-07, status=1, ipAttribution=)]
    2020-11-09 Jessica

    摄入较高的植物脂肪和多不饱和脂肪与较低的HCC风险有关。用植物脂肪代替动物或乳制品脂肪,或用单不饱和或多不饱和脂肪代替饱和脂肪与降低HCC的风险有关。 多吃蔬菜,多吃不饱和脂肪酸

    0

  7. 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encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 05 17:05:22 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712597, encodeId=6f651e1259777, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Mar 04 23:05:22 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897957, encodeId=6c0989e95719, content=摄入较高的植物脂肪和多不饱和脂肪与较低的HCC风险有关。用植物脂肪代替动物或乳制品脂肪,或用单不饱和或多不饱和脂肪代替饱和脂肪与降低HCC的风险有关。 多吃蔬菜,多吃不饱和脂肪酸 , beContent=null, objectType=article, 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  8. 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  9. 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createdTime=Sat Nov 07 12:33:01 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897550, encodeId=da1e89e5504c, content=多吃蔬菜水果, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sat Nov 07 11:57:25 CST 2020, time=2020-11-07, status=1, ipAttribution=)]
    2020-11-07 1393d772m33暂无昵称

    这个说的好

    0

  10. 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createdTime=Sat Nov 07 12:33:01 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897550, encodeId=da1e89e5504c, content=多吃蔬菜水果, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sat Nov 07 11:57:25 CST 2020, time=2020-11-07, status=1, ipAttribution=)]
    2020-11-07 Ash.L

    多吃蔬菜水果

    0

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