Nat Rev Microbiol:宏基因组关联分析与微生物组

2016-07-13 MedSci MedSci原创

我们体内生活着不计其数的微生物,它们组成的生态系统就是微生物组。近年来人们发现这些微生物对人体健康有着重要的影响,微生物组研究因此受到了极大的重视,甚至被称为是人体的“第二基因组”。宏基因组关联分析(Metagenome-wide association studies,MWAS)是挖掘微生物组宝藏的有力工具,可以高分辨率研究微生物组与复杂疾病的关联,比如二型糖尿病、肥胖症、肝硬化、大肠癌和类风湿

我们体内生活着不计其数的微生物,它们组成的生态系统就是微生物组。近年来人们发现这些微生物对人体健康有着重要的影响,微生物组研究因此受到了极大的重视,甚至被称为是人体的“第二基因组”。


宏基因组关联分析(Metagenome-wide association studies,MWAS)是挖掘微生物组宝藏的有力工具,可以高分辨率研究微生物组与复杂疾病的关联,比如二型糖尿病、肥胖症、肝硬化、大肠癌和类风湿性关节炎。MWAS不仅能鉴定丰度发生变化的细菌种类,还能够判断细菌功能的增强或减弱。

iCarbonX公司CEO王俊和华大基因BGI的Huijue Jia最近在Nature Reviews Microbiology杂志上发表文章,介绍了MWAS研究最近的一些发现,探讨了这些发现对疾病预防、诊断和治疗的潜在影响。文章指出,我们需要在人类微生物组中更好地描述细菌生物学特性,这样才能理解MWAS鉴定的细菌菌株与疾病有何关系。

微生物组参与了许多重要的机体功能,比如消化食物、合成营养物质和抵御疾病。许多人类疾病都与微生物组失衡有关,但揭示其中的因果关系并不容易。因为微生物组是由数百种细菌组成的复杂生态系统,同种细菌的不同菌株也存在显著的遗传差异。

原始出处:

Wang J, Jia H. Metagenome-wide association studies: fine-mining the microbiome. Nat Rev Microbiol. 2016 Jul 11. doi: 10.1038/nrmicro.2016.83

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    2016-07-15 liye789132251
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    2017-06-09 xjy02
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    2016-10-17 sunylz
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