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GUT：粪便微生物移植可改善中重度肠易激综合征患者临床症状

2018-07-07 zhangfan MedSci原创

肠易激综合征粪便微生物移植FMT
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随机双盲安慰剂对照研究证实，肠易激综合征患者接受粪便微生物移植对患者临床症状及菌群多样性有积极影响

肠易激综合征与肠道菌群失调有关，粪便微生物移植（FMT）已被认为对IBS患者有积极作用。近日研究人员开展随机、双盲、安慰剂对照研究考察IBS患者接受FMT后肠道微生物及临床症状的变化。

52名中重度IBS患者参与研究，收集基线临床史、症状以及粪便样本资料，随机接受FMT或安慰剂胶囊治疗持续12天，随访6个月。在基线、1、3、6个月对患者进行IBS症状（IBS-SSS）以及IBS相关生活质量(IBS-QoL)评估。 研究发现，相对于安慰剂，FMT治疗后3个月，患者IBS-SSS(p=0.012)及IBS-QoL(p=0.003)得分显著改善，FMT治疗患者其粪便微生物生物多样性增加，安慰剂组则无显著变化。

随机双盲安慰剂对照研究证实，肠易激综合征患者接受粪便微生物移植对患者临床症状及菌群多样性有积极影响。

原始出处：


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    2019-03-14 wjcjjian

    #微生物#

    0

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    2018-09-01 whmdzju

    #临床症状#

    0

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    2018-11-19 pps20031

    #粪便微生物#

    0

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jul 15 06:12:52 CST 2018, time=2018-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330569, encodeId=b44633056938, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue Jul 10 08:47:48 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431260, encodeId=2427143126084, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-15 jyzxjiangqin

    粪便微生物移植.

    0

  5. 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-10 大爰

    学习并分享!!

    0

  6. 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-08 zhouqu_8

    #综合征#

    0

  7. 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-08 Homburg

    #粪便#

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=330206, encodeId=dec2330206a9, content=粪便微生物移植., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jul 08 20:43:41 CST 2018, time=2018-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330048, encodeId=3e96330048b7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Jul 07 20:46:04 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-08 jyzxjiangqin

    粪便微生物移植.

    0

  9. 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 海之蓝

    学习

    0

  10. 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topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jul 08 21:30:00 CST 2018, time=2018-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466823, encodeId=1a451466823a7, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Sun Jul 08 21:30:00 CST 2018, time=2018-07-08, status=1, ipAttribution=), 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time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329956, encodeId=c5a6329956ec, content=不错.效果也很显著!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC8Ent800APm6O03QRBUr3SF7zVb8FI5jYx8B9B9wYvXT9aoeveU0sNrF3qgNhicyT9dOFGN7FLhjw/0, createdBy=c8c01966513, createdName=张辉, createdTime=Sat Jul 07 10:36:50 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 张辉

    不错.效果也很显著!

    0

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Curr Opin Clin Nutr Metab Care：肠易激综合征和饮食——2018年我们在哪里？

过去五十年来，关于IBS饮食管理的研究数量急剧增加，研究干预的重点，规模和复杂程度各不相同。最初，许多研究调查膳食纤维在IBS管理中的作用，至少包括14项随机对照试验

维生素D补充剂可有效缓解疼痛性肠易激综合征

英国谢菲尔德大学的一项最新研究发现，维生素D补充剂有助于缓解疼痛性肠易激综合征（IBS）的相关症状。研究人员整合了所有关于维生素D和IBS的研究，发现IBS患者伴有维生素D缺乏症的比率较高，同时该现象与种族无关。

2017 韩国肠易激综合征临床实践指南（修订版）

2018年4月，韩国神经胃肠病学与动力学会(KSNM)发布了肠易激综合征临床实践指南2017修订版，肠易激综合征是一种常见的功能性胃肠疾病，本文是对KSNM2011年发布了肠易激综合征管理指南的更新，主要包括4个主题内容，分别为肠镜检查，饮食干预，益生菌和利福昔明的应用。

J Gastroen Hepatol：饮食习惯与青春期肠易激综合征之间的关系

汤泡饭、咀嚼不足、牙齿脱落率高、辛辣和油炸食物导致青春期少女肠易激综合征风险增加