Nat Med:黑色素瘤患者与免疫检查点阻断毒性相关的T细胞特征

2022-01-14 MedSci原创 MedSci原创

这些结果证明了与免疫检查点抑制剂诱导的毒性相关的循环T细胞特征,这对改进黑色素瘤的临床诊断和治疗具有重要意义。

免疫检查点抑制剂已经成为晚期黑色素瘤的标准治疗方案,且开始应用于局部晚期黑色素瘤患者切除术后的辅助治疗中,从而使晚期黑色素瘤患者获得长期生存。但是在接受免疫检查点抑制剂治疗的黑色素瘤患者中,高达60%的患者会发生严重的免疫相关不良事件。然而,尚不清楚在免疫相关不良事件发生发展之前是否存在共同的基线免疫状态。

近日,顶级医学期刊Nature Medicine上发表了一篇研究文章,在这项研究中,研究人员通过飞行时间质谱、单细胞RNA测序、单细胞V(D)J测序、bulk RNA测序和bulk T细胞受体(TCR)测序来探究来自接受PD-1单一疗法或抗PD-1和抗CTLA-4联合免疫检查点抑制剂治疗的黑色素瘤患者外周血样本。

研究人员通过分析93个接受免疫检查点抑制剂治疗前和治疗早期的血液样本以及3个患者队列(n=27、26和18),研究人员发现循环中2个治疗前因素—激活的CD4阳性记忆T细胞丰度和TCR多样性—与严重的免疫相关不良事件发生发展相关,无论器官系统受累情况如何。

研究人员还探讨了接受联合治疗的黑色素瘤患者TCR克隆性的治疗变化,并将该研究的结果与免疫相关不良事件发作的严重程度和时间联系起来。

由此可见,这些结果证明了与免疫检查点抑制剂诱导的毒性相关的循环T细胞特征,这对改进黑色素瘤的临床诊断和治疗具有重要意义。

原始出处:

Alexander X. Lozano,et al.T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma.Nature Medicine.2022.https://www.nature.com/articles/s41591-021-01623-z

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    2022-06-24 sunylz
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    2022-09-12 liye789132251
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1680782, encodeId=b6391680e8200, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Fri Jun 24 07:15:03 CST 2022, time=2022-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710302, encodeId=ff8e1e103020e, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Fri Nov 25 11:15:03 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885602, encodeId=183c188560230, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 12 03:15:03 CST 2022, time=2022-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340600, encodeId=36b8134060060, content=<a href='/topic/show?id=dd1a29055c8' target=_blank style='color:#2F92EE;'>#免疫检查点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29055, encryptionId=dd1a29055c8, topicName=免疫检查点)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Sun Jan 16 02:15:03 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559112, encodeId=1c73155911230, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sun Jan 16 02:15:03 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565121, encodeId=6f431565121cb, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Sun Jan 16 02:15:03 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611408, encodeId=315f1611408a0, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 16 02:15:03 CST 2022, time=2022-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184377, encodeId=434211843e7d5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebcd6454890, createdName=ms4000000927134137, createdTime=Fri Jan 14 20:55:41 CST 2022, time=2022-01-14, status=1, ipAttribution=)]
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    2022-01-14 ms4000000927134137

    学习了

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