JAMA Psychiat:用认知行为疗法治疗合并焦虑的自闭症儿童

2019-11-25 QQY MedSci原创

焦虑在患有自闭症谱系障碍(ASD)的年轻人中很常见,常常会干扰他们的适应能力。心理治疗常用来治疗学龄期青少年ASD;但其功效尚未确定。研究人员开展一随机化临床试验,对比两种认知行为疗法(CBT)和常规治疗(TAU)的相对疗效,评估用于ASD患儿适应不良和干扰性焦虑的治疗效果;同时评估其对于正性反应、ASD症状严重性和焦虑相关试验功能的治疗效果。招募7-13岁的合并适应不良和干扰性焦虑的ASD患儿,

焦虑在患有自闭症谱系障碍(ASD)的年轻人中很常见,常常会干扰他们的适应能力。心理治疗常用来治疗学龄期青少年ASD;但其功效尚未确定。

研究人员开展一随机化临床试验,对比两种认知行为疗法(CBT)和常规治疗(TAU)的相对疗效,评估用于ASD患儿适应不良和干扰性焦虑的治疗效果;同时评估其对于正性反应、ASD症状严重性和焦虑相关试验功能的治疗效果。招募7-13岁的合并适应不良和干扰性焦虑的ASD患儿,随机分至标准CBT组、ASD适应性CBT组或TAU组。主要评估指标是儿科焦虑评定量表。次要结果包括临床整体印象改善量表和检查表测量的治疗反应。

共招募了214位患儿,167位(其余不符合纳入标准)被随机分至三组,145位完成治疗,22位撤出研究。不同情况下的停药率没有显著差异。随机分组儿童的平均9.9岁;其中女童34人(20.5%)。根据儿科焦虑评定量表,ASD适应性CBT的效果优于标准CBT和TAU(平均量表评分分别是2.13 vs 2.43 vs 2.93)。根据家长报告的内化症状量表或ASD相关的社交症状以及焦虑相关的社交症状,ASD适应性CBT的效果仍均优于标准CBT和TAU。对于正性治疗反应,ASD适应性CBT和标准CBT组的效果均优于TAU组。

综上所述,CBT可有效治疗ASD合并干扰性焦虑的患儿,而且适应性CBT方法的治疗效果更为突出。推荐为学龄期ASD患儿提供心理治疗的临床医生可以考虑进一步研习CBT专业知识。

原始出处:

Jeffrey J. Wood, et al.Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder.JAMA Psychiatry. November 22, 2019. doi:https://doi.org/10.1001/jamapsychiatry.2019.4160

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    2019-11-27 xiongke014
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    2019-11-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1709826, encodeId=de0e1e098266b, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Apr 10 16:33:00 CST 2020, time=2020-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075997, encodeId=29ae20e5997a4, content=<a href='/topic/show?id=b1329003e13' target=_blank style='color:#2F92EE;'>#行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90037, encryptionId=b1329003e13, topicName=行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Sun Aug 16 08:33:00 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337701, encodeId=94b1133e7015f, content=<a href='/topic/show?id=bf019126469' target=_blank style='color:#2F92EE;'>#认知行为疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91264, encryptionId=bf019126469, topicName=认知行为疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Wed Nov 27 11:33:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527769, encodeId=54dc152e76946, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Wed Nov 27 11:33:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035811, encodeId=6d0110358117b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Nov 25 23:33:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050510, encodeId=1a97105051055, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Nov 25 23:33:00 CST 2019, time=2019-11-25, status=1, ipAttribution=)]
    2019-11-25 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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