JAD:草莓竟可以抵御阿尔茨海默症!

2022-08-01 转化医学网 网络

草莓中生物活性物质天竺葵素的摄入较高与AD神经病理学较少有关,主要是磷酸化的tau缠结。

花青素天竺葵素主要存在于浆果中,具有抗氧化和抗炎特性,研究人员为了探索天竺葵素或浆果的摄入是否与人脑阿尔茨海默氏症(AD)神经病理学有关。他们对Rush记忆与衰老项目的575名死亡受试者进行研究,包括饮食数据(使用食物频率问卷评估)和神经病理学评估。得出结论:草莓中生物活性物质天竺葵素的摄入较高与AD神经病理学较少有关,主要是磷酸化的tau缠结。

根据RUSH研究人员的一项新研究表明草莓作为零食,麦片或沙拉可以帮助保护我们的大脑免受阿尔茨海默氏症的侵害。该研究发布于《Journal of Alzheimer's Disease》

640

https://pubmed.ncbi.nlm.nih.gov/35694918/

天竺葵素

RUSH研究人员发现,在草莓中发现的一种叫做天竺葵素的生物活性化合物,天竺葵色素又称花葵素,它可能与大脑中较少的神经原纤维tau缠结有关。Tau缠结是阿尔茨海默病的标志之一,这是由大脑中积累的tau蛋白的异常变化引起的。

施耐德博士说“我们怀疑天竺葵素的抗炎特性可能会减少整体神经炎症,这可能会减少细胞因子的产生。”

细胞因子是由细胞产生的蛋白质,可以调节各种炎症反应。大脑中的炎症与阿尔茨海默氏症的病理学有关,如斑块和缠结。数据表明,天竺葵素可以保护衰老的大脑免受阿尔茨海默病病理学的侵害。

而在浆果中,草莓是天竺葵素最丰富的来源。

RADC与MAP

RUSH研究人员研究了他们从RADC正在进行的长期研究中获得的数据,该研究于1997年开始,由RADC,MAP进行。在随访和脑尸检期间,共有575名死亡参与者具有完整的饮食信息,其平均死亡年龄为91.3岁。共有452人是APOE 4基因的非携带者,共有120名参与者患有APOE 4,这是阿尔茨海默病最强的遗传危险因素基因。参与者使用食物频率问卷对饮食进行评估,在死亡前进行长达近20年的随访,并在死后进行标准化的神经病理学评估。

在研究过程中,每个人都接受了五个领域的年度标准化认知能力测试即情节记忆,工作记忆,语义记忆,视觉空间能力和感知速度。

MAP包括65岁及以上的人,他们是伊利诺伊州北部40多个退休社区和高级公共住房单元的居民。那些参加的人大多是白人,没有已知的痴呆症,所有参与者都同意在活着的时候进行年度临床评估,并在死后进行脑尸检。在研究人员调整了可能影响记忆和思维技能的其他因素后,结果相同,例如教育,APOE 4状态,维生素E和维生素C。在基线时没有痴呆或轻度认知障碍的人中,这些关联更为强烈。

局限与展望

然而研究人员表示:“我们没有在与阿尔茨海默病相关的APOE 4基因的人中观察到相同的效果,但这可能是由于这项研究中具有该基因的个体的样本量较小。”

尽管这项研究是一项观察性研究,并没有证明直接的因果关系。仍需要进一步的研究来了解营养在阿尔茨海默病中的作用,但这项研究给了我们关于浆果等特定饮食成分如何帮助大脑健康的希望

参考资料:

https://medicalxpress.com/news/2022-07-strawberries-fend-alzheimer.html

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    2022-08-02 wgsun

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接种至少一剂流感疫苗的人在四年内患阿尔茨海默病 (AD) 的风险降低了40% 。

“好胆固醇”的又一好处!研究揭示HDL可预防阿尔茨海默症

众所周知,血脂高是诱发心脑血管疾病原因之一,新研究显示,胆固醇和血糖水平可以最大限度地降低未来患阿尔兹海默症的风险。

鱼油不是智商税?研究发现,血液中DHA含量高,患阿尔茨海默症风险下降5成!

Nutrients: 血液中DHA水平较高的人患阿尔茨海默症的可能性比水平较低的少49%。而增加DHA的摄入量可能会降低患AD的风险,这一关联在携带载脂蛋白E4等位基因的AD高风险个体更显著。

Neurology:无症状老年人APOE非依赖性阿尔茨海默病多基因风险评分与脑淀粉样蛋白沉积的关系

脑淀粉样沉积是阿尔茨海默病(AD)的主要危险因素。依赖于AD遗传风险因素(不包括APOE)的PRSS可以改善脑淀粉样蛋白的风险预测,允许对认知正常的AD风险个体进行分层,而不依赖于他们的APOE状态。

5年蝉联第一的「地中海饮食」,还能降低痴呆风险!近25万人研究揭示其“防痴呆密码”

JAMA子刊:高度依从地中海饮食模式,与更高的认知能力、更少的学习能力和记忆下降有关,即坚持地中海饮食可能会降低人群认知能力下降以及阿尔茨海默症风险。

氢气的医学用途:氢气联合tDCS对老年痴呆(阿尔茨海默症)预防和康复的积极意义

tDCS应用于阿尔茨海默症的治疗,具有广阔的应用前景;同时,氢气通过抑制氧化应激治疗阿尔茨海默症,并且氢气作为气体分子,具有易扩散、起效快、无明显不良反应等优点。二者联合,有望成为阿尔茨海默病康复治疗