J Trauma Acute Care Surg:败血症、创伤和烧伤中危重疾病的长期后遗症——一项系统回顾和荟萃分析结果

2021-11-29 MedSci原创 MedSci原创

败血症、重大创伤和严重烧伤是威胁生命的危急疾病,仍然是全世界发病率和死亡率的重要因素。这三种基本病因在病理生理上有相似之处:过度炎症、高代谢和急性免疫调节。

败血症、重大创伤和严重烧伤是威胁生命的危急疾病,仍然是全世界发病率和死亡率的重要因素。这三种基本病因在病理生理上有相似之处:过度炎症、高代谢和急性免疫调节。近日,发表于 J Trauma Acute Care Surg的一项系统回顾评估长期结果研究的现状,并确定这三种形式的危重病的关键结果参数。

研究人员检索了1975年1月1日至2019年12月31日PubMed收录的相关文章。研究由独立审查员进行资格评估。纳入标准是在严重烧伤、败血症和重大创伤这三种病因中,报告至少6个月的健康相关生活质量和特定器官后遗症的研究。

结果,共有125篇文章可以被纳入系统回顾,74篇文章被纳入MA。分析结果显示,与脓毒症和创伤研究相比,烧伤研究的平均随访时间明显更长。大多数患者来自败血症组,其次是烧伤和重大创伤研究。在与健康有关的总体生活质量方面,根据短表格36和欧洲生活质量指数的评估,三种不同的病因相互之间具有可比性。最重要的是,严重烧伤、脓毒症或严重创伤的幸存者在MA时均未达到正常水平的关键QoL指标

综上所述,该研究结果表明,危重病对幸存者的影响在住院后仍持续多年。需要更多关于严重烧伤、败血症和重大创伤这三种疾病的长期结果的良好报告和可靠数据,来帮助医生确定治疗选择和指导患者的期望,从而改善三个重要患者群的整体护理质量。

 

原始出处:

Valentin F Haug, et al., Long-term sequelae of critical illness in sepsis, trauma and burns: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2021 Oct 1;91(4):736-747. doi: 10.1097/TA.0000000000003349.

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    2022-07-20 venlin
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    2022-10-31 bsmagic9140
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    2022-04-23 siiner
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    2021-12-01 bshuang
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