BMJ：基于肠促胰素的药物不会增加胰腺癌风险

2016-02-18 Mechront 译 MedSci原创

研究者对2型糖尿病患者进行了一项基于人群的队列研究，比较基于肠促胰素的药物和磺脲类药物，是否会增加胰腺癌风险。该大型国际多中心的研究在加拿大、美国和英国的六个地点进行，共纳入了2007-1-1至2013-6-30的972 384名患者，随访到2014-6-30.在每一个队列中，研究者都进行了嵌套病例对照分析，胰腺癌与对照组按1:20进行匹配（性别、年龄、进入队列日期、治疗糖尿病的持续时间和随访时间

研究者对2型糖尿病患者进行了一项基于人群的队列研究，比较基于肠促胰素的药物和磺脲类药物，是否会增加胰腺癌风险。

该大型国际多中心的研究在加拿大、美国和英国的六个地点进行，共纳入了2007-1-1至2013-6-30的972 384名患者，随访到2014-6-30。

在每一个队列中，研究者都进行了嵌套病例对照分析，胰腺癌与对照组按1：20进行匹配（性别、年龄、进入队列日期、治疗糖尿病的持续时间和随访时间等）。评估使用基于肠促胰素的药物和使用磺脲类药物相比下，患者的胰腺癌危险比和95%可信区间。此外还进行二次分析，探究风险是否与药物（二肽基肽酶抑制剂和胰高血糖素样肽-1受体激动剂）或使用时间（从治疗开始使用时间和累计时间）有关。使用随机效应模型计算合并后的危险比。

研究数据显示，在长达2 024 441 人/年的随访中（中位数随访1.3-2.8年，最长达8年），有1221名患者新诊断为胰腺癌（发生率为0.60/1000人年）。与磺脲类药物相比，基于肠促胰素的药物不会增加胰腺癌风险（合并后aHR=1.02, 95% CI 0.84 to 1.23）。风险也没有因为药物种类、使用时间等发生变化。

该以人口为基础的大型研究表明，使用基于肠促胰岛素的药物并不增加患胰腺癌的风险（与磺脲类药物相比）。尽管由于癌症的潜伏期，这种潜在的药物不良反应将需要长期的监测，但当前的发现为基于肠促胰素的药物安全提供了一些安慰。

原始出处：

Laurent Azoulay, Kristian B Filion,et al.Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study.BMJ 2016; 352 doi: http://dx.doi.org/10.1136/bmj.i581

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2016-12-31 sjq027

#癌风险#

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2016-03-25 xfpan12

#肠促胰素#

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2016-09-11 gaoxiaoe

#BMJ#

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2016-04-10 忠诚向上

值得学习

127 0
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2016-04-10 忠诚向上

值得学习

55 0
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2016-04-10 忠诚向上

值得学习

114 0
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2016-04-10 忠诚向上

值得学习

86 0
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2016-04-10 忠诚向上

值得学习

88 0
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2016-04-10 忠诚向上

值得学习

94 0
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