PLoS Biol:运动,真的能让食欲下降?

2018-04-26 佚名 中国生物技术网

有没有想过,为什么剧烈运动会让你暂时忘掉美食的诱惑?

有没有想过,为什么剧烈运动会让你暂时忘掉美食的诱惑?

根据刚发表在《PLOS Biology》上的一项新研究,美国阿尔伯特爱因斯坦医学院的科学家揭示出,这个问题的答案就在你的大脑中——具体地说,就是你的弓状核。

这项研究的通讯作者是医学和分子药理学副教授Young-Hwan Jo博士。他每周在家附近跑步三次,每次30至45分钟。像很多运动的人一样,他也发现了关于剧烈运动后的两个现象:在运动后的一段时间内体温上升,但食欲会下降。


Young-Hwan Jo博士

他说:“我是从事下丘脑研究的,这个大脑区域在调节代谢和体重方面发挥着核心作用。我猜测,如果特定的下丘脑神经元感受到体温上升,就会对运动产生的热量进行反应,方式就是释放出‘不要吃东西’的信号。”

经历过酷热或吃过辣椒的人都会知道身体中充满着带有“hot”受体(TRPV1受体)的感知神经元。这些神经元会对身体的热和辣椒素起反应,辣椒素是存在于墨西哥辣椒和很多其他辣味食物中的活性成分。大脑神经元也拥有类似的受体吗?

于是,Jo博士开始关注下丘脑中的弓状核(ARC)中抑制食欲的阿黑皮素原(POMC)神经元。他发现,这些神经元中的一部分并没有受到血脑屏障的防护,所以它们能够直接检测到血液中的激素和营养物质并进行反应。他想弄清楚这些神经元是否也会感知到身体中的温度变化。

为了感知和响应热量,ARC中的POMC神经元需要在身体其他地方发现类似对辣椒素和热敏感的TRPV1受体。Jo博士和同事们采集了含有POMC神经元的小鼠下丘脑组织,并将该组织暴露在辣椒素或热的环境中,以验证这种受体是否存在。

毫无疑问,辣椒素和热都会导致POMC神经元通过激活受体的方式释放脉冲。ARC中的POMC神经元大约有三分之二拥有这种受体。接下来的实验探究了POMC神经元和它们的TRPV1受体在减轻食欲和抑制进食方面的作用。Jo博士和同事们发现:

向小鼠的ARC内注入辣椒素会减少小鼠在接下来12个小时内的进食量。研究人员能够通过首先阻断POMC神经元的类TRPV1受体,或关闭为这些受体编码基因的方式来阻止食欲抑制作用。

小鼠在跑步机上运动40分钟之后,它们的身体和ARC温度都会快速上升,在20分钟后稳定,并会在接下来的一个多小时仍然保持在较高温度。运动之后的小鼠的进食量比不运动的小鼠减少了50%。

对于ARC中POMC神经元缺少TRPV1受体的小鼠来说,运动不会影响它们的进食量。

Jo博士说:“我们的研究证明,体温可以起到调节进食行为的生物信号的作用,就像某些激素和营养物质一样。”他还指出,这项发现有助于人们开发出新型抑制食欲的方法以帮助人们减肥。

原始出处:Jeong JH, Lee DK1, Liu SM, et al. Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol. 2018 Apr 24;16(4):e2004399. 

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  4. 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  5. 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createdTime=Fri Apr 27 08:28:56 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309735, encodeId=1d8c309e35ca, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:24:29 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-28 lofter

    学习了感谢分享

    0

  6. 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createdTime=Fri Apr 27 08:28:56 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309735, encodeId=1d8c309e35ca, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:24:29 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-28 小贝熊

    学习学习学习

    0

  7. 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createdTime=Fri Apr 27 08:28:56 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309735, encodeId=1d8c309e35ca, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:24:29 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 天地飞扬

    了解一下.谢谢分享!

    0

  8. 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createdTime=Fri Apr 27 08:28:56 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309735, encodeId=1d8c309e35ca, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:24:29 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 flysky120

    运动的时候食欲降低.但是运动休息过一段时间后再次进食量会上升的.

    0

  9. 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createdTime=Fri Apr 27 08:28:56 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309735, encodeId=1d8c309e35ca, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:24:29 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 龙胆草

    学习谢谢分享

    0

  10. 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    2018-04-27 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

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