Arthritis Rheumatol:MRI评估的软骨下囊肿与膝关节疼痛和骨关节炎的关系

2021-07-18 MedSci原创 MedSci原创

软骨下囊肿很可能是RKOA的次要表现,而不是主要触发因素,并且可预测既往有疾病的膝盖症状。

近日,风湿免疫学领域权威杂志Arthritis & Rheumatology上发表了一篇研究文章,研究人员旨在评估通过磁共振成像(MRI)测量的膝关节软骨下囊肿是否与膝关节骨关节炎(OA)的结局相关。


研究人员使用了多中心骨关节炎研究(MOST)的纵向数据,该研究是一个基于社区的膝关节OA危险因素队列。没有膝关节手术史和/或炎症性关节炎(即类风湿性关节炎和痛风)病史的参与者对事件结局进行了为期84个月的随访;主要关注i)膝关节OA(RKOA)(Kellgren-Lawrence(KL)≥2),ii)有症状的RKOA(RKOA和频繁的膝关节疼痛)和iii)频繁的膝关节疼痛(有/没有RKOA的参与者)。

研究人员对一个亚组的膝盖MRI上的软骨下囊肿进行评分。多元逻辑回归,调整参与者特征和其他基线膝关节MRI结局,用于评估软骨下囊肿是否可预测事件结局。

软骨下囊肿与RKOA之间的关联

 
该研究中符合每个结局的参与者分别有22.8%、17.0%和28.8%(无RKOA)/43.7%(有RKOA)发生RKOA、症状性RKOA和频繁膝关节疼痛。调整年龄、性别和BMI后,软骨下囊肿与RKOA的发生无关,但与有症状的RKOA(OR:1.92(95%CI:1.16至3.19))和RKOA患者膝关节疼痛(2.11(0.87to5.12))的发生几率增加相关。
 
由此可见,软骨下囊肿很可能是RKOA的次要表现,而不是主要触发因素,并且可预测既往有疾病的膝盖症状。

原始出处:

Thomas A. Perry,et al.MRI-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: data from the Multicentre Osteoarthritis Study. Arthritis Rheumatol. 2021.https://doi.org/10.1002/art.41917

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    2022-04-17 lisa438
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    2021-07-20 lmm397
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    2021-07-20 zhaojie88

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Ann Rheum Dis:华法林与膝关节和髋关节置换风险

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Ann Rheum Dis:使用维生素K拮抗剂与骨关节炎发病和进展的风险升高相关

这些发现支持了维生素K和维生素K依赖性蛋白(如MGP)在OA发病中的重要性。

Ann Intern Med:莪术提取物治疗膝关节炎症状和积液性滑膜炎的效果

目前骨关节炎患者的药物治疗方法均不理想。近日,一项随机、双盲、安慰剂对照试验测定了莪术提取物(CL)对有症状的膝关节骨关节炎和膝关节积液-滑膜炎患者减轻膝关节症状的疗效,研究结果已发表于Ann Int