JEADV:小剂量口服米诺地尔增加雄激素性脱发患者头发密度和厚度

2021-12-03 医路坦克 MedSci原创

虽然外用米诺地尔一直是雄激素性脱发(AGA)的主要治疗方法,但口服米诺地尔直到最近才被研究。LDOM是一种耐受性良好的治疗方法,与其他药物联合使用时密度增加.

     虽然外用米诺地尔一直是雄激素性脱发(AGA)的主要治疗方法,但口服米诺地尔直到最近才被研究。以前的研究表明,小剂量口服米诺地尔(LDOM)是一种有效的、耐受性良好的AGA疗法。

     我们对2016年1月1日至2019年12月15日期间在纽约大学朗格尼健康中心接受LDOM治疗的60名AGA患者进行了回顾性图表回顾(表1)。使用Folliscope(LeadM公司,韩国,首尔)对57例患者进行顶中央头皮(CP,眉间上方8-14 cm)和9例头顶(眉间上方24-30 cm)的三倍体测量。患者在接受其他治疗的同时,每天服用0.625-5.0mgLDOM,与以前文献中报道的剂量相似(表1)。采用STATA/IC(StataCorp LLC,College Station,TX,USA,USA)进行的单侧样本测试和双样本比例测试进行了分析。在STATA/IC(STATA/IC)(StataCorp LLC,College Station,TX,USA)上,每天给患者开0.625-5.0mgLDOM。毛发/cm2增加13.9根/cm2(D9.1%,P<0.01)。头顶平均增加10.4根/cm2(D6.9%,P=0.34)(表1)。毛干直径在头端增加了约4.5lm(D8.4%,P<0.01),在顶端增加了7.6lm(D13.8%,P<0.05;表1)。男性(15.0根/cm2,D10.3%,P<0.01)和女性(13.5根/cm2,D8.7%,P<0.01)的毛发密度显著增加。男性(4.9lm,D9.6%,P=0.03)和女性(4.3lm,D7.8%,P=0.02)的CP口径均显著增加。在治疗的任何时间点使用米诺地尔和LDOM的患者与不使用米诺地尔的患者之间在密度或口径上没有显著差异。由于同时用药的混杂效应,对31名患者进行了亚组分析,这些患者在开始LDOM的同时或之后没有开始服用新的AGA药物(表1)。密度在CP组显著增加(9.4根/cm2,D5.7%,P=0.02;表1)。24例(40.0%)患者报告了副作用。20例(33.3%)报告多毛症,5例(8.3%)报告下肢水肿。女性报告多毛症的可能性更大(P<0.01;表1)。<30岁的患者报告的副作用明显少于60岁的≥患者(P<0.0 5;表1)。 

 

表1患者人口统计、同时用药和副作用

 

 

    研究发现CP的密度持续显著增加。大多数人都能耐受LDOM治疗,这与之前发表的研究一致。尽管男性和女性的头顶密度都有所增加(表1),但与Jhaet等人的结果相比,两组患者的头顶密度都没有显著增加。值得注意的是,本研究中较少的患者在头顶进行了毛镜测量,进一步的研究,特别是更大规模的随机对照研究,将有助于阐明LDOM在AGA治疗中的作用。

图1  相隔12个月拍摄的患者顶顶中央和顶端头皮的全球临床照片。患者的头皮覆盖中央顶端有了改善,而头皮看起来更稳定。*患者开始服用1.25毫克/天的米诺地尔、2.5毫克/天的非那雄胺和5%的米诺地尔溶液,患者每隔一天自我转换到5%的米诺地尔泡沫剂。在这一年中,另一位医生每天给她服用25毫克的螺内酯,时间不详。

 

   总体而言,LDOM是一种耐受性良好的治疗方法,与其他药物联合使用时密度增加(图1)。AGA治疗具有挑战性,LDOM是一个很有潜力的补充,特别是对于那些没有达到他们想要的改善和副作用无法使用其他药物的患者。

 

文献来源: Yin L,  Svigos K,  Gutierrez D, Low-dose oral minoxidil increases hair density and thickness in androgenetic alopecia: a retrospective analysis of 60 patients,J Eur Acad Dermatol Venereol 2021 Oct 12;

 

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    2023-02-07 ms5000001410456216 来自海南省

    头上没长,都长脸上了

    0

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    2022-05-25 pyaili
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    2021-12-04 qindq
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    2021-12-03 病毒猎手

    #米诺地尔#增加雄激素性#脱发#,被证实了

    0

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