Gut:DNA含量流式检测在巴雷特食管诊断和风险分层评估的应用

2017-06-23 zhangfan MedSci原创

福尔马林固定石蜡包埋组织样本DNA流式检测可用于巴雷特食管的诊断和发育不良风险分层评估,DNA含量异常与疾病进展程度相关

巴雷特食管(BO)不典型增生的诊断是极具挑战性的,目前尚无可靠的检测技术。近日研究人员考察了福尔马林固定石蜡包埋(FFPE)患者样本,使用流式细胞DNA含量检测法在轻度不典型增生(LGD) 和不确定的不典型增生(IND)的危险分层中的应用前景。

研究人员分别采集了80例高度分化不良(HGD)、38例LGD、21例IND以及14例对照样本,制成3-4个60微米厚的切片。

研究发现,76例HGD(95%)、8例LGD (21.1%)、2例IND (9.5%)以及0例ND样本存在DNA含量异常。作为高度分化不良的诊断标记,DNA含量异常的敏感性以及特异性分别为95% 和85%。随访发现,对于DNA含量异常的基线LGD或IND患者,单变量的高度分化巴雷特食管或食管腺癌的风险分别为7.0和20.0。

研究认为,福尔马林固定石蜡包埋组织样本DNA流式检测可用于巴雷特食管的诊断和发育不良风险分层评估,DNA含量异常与疾病进展程度相关,HGD样品显示95%的 DNA含量异常。DNA流式检测也可用于疾病早期患者疾病进展的预计。

原始出处:


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    2018-03-27 owlhealth

    不错耶.学习了

    0

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    2017-07-07 虈亣靌

    这个可以啊,不错

    0

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    2017-06-25 zhouqu_8
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    2017-06-24 清风拂面

    谢谢分享,学习了

    0

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