J Bone Miner Res:几种降压药与PTH

2016-03-19 Mechront 译 MedSci原创

噻嗪类利尿剂(TZ)与更高的骨密度相关,而袢利尿剂(LD)与更低的骨密度和骨折相关。甲状旁腺细胞可表达二氢吡啶敏感的钙通道,可能在甲状旁腺素(PTH)调节中发挥作用。利尿剂和钙通道阻滞剂(CCBs)调节PTH和钙平衡间可能存在一个潜在的影响骨骼结局的机制。研究者假设,使用LD和二氢吡啶类CCBs会增高PTH,而TZ会降低PTH。因此研究者进行了一项横断面研究,纳入了多种族动脉粥样硬化研究中的188

噻嗪类利尿剂(TZ)与更高的骨密度相关,而袢利尿剂(LD)与更低的骨密度和骨折相关。甲状旁腺细胞可表达二氢吡啶敏感的钙通道,可能在甲状旁腺素(PTH)调节中发挥作用。利尿剂和钙通道阻滞剂(CCBs)调节PTH和钙平衡间可能存在一个潜在的影响骨骼结局的机制。研究者假设,使用LD和二氢吡啶类CCBs会增高PTH,而TZ会降低PTH。

因此研究者进行了一项横断面研究,纳入了多种族动脉粥样硬化研究中的1888名治疗高血压、没有原发性甲状旁腺功能亢进或慢性肾脏病的患者。使用校正后回归模型评估TZ、LD和CCB对PTH的影响。

研究数据显示,与非TZ使用者相比,使用TZ会降低PTH水平(44.4 vs. 46.9 pg/mL, p = 0.02),而LD和CCBs会增加PTH水平(LD: 60.7 vs. 45.5 pg/mL, p < 0.0001; CCB: 49.5 vs. 44.4 pg/mL, p < 0.0001)。校正后回归模型分析,确认了使用TZ会降低PTH水平(β = -3.2 pg/mL, p = 0.0007),以及LD或CCB会增高PTH水平(LD: β = +12.0 pg/mL, p < 0.0001; CCB: +3.7 pg/mL, p < 0.0001)。CCB使用者中,只有二氢吡啶类CCB会增高PTH(β= +5.0 pg/mL, p < 0.0001),非二氢吡啶类CCB不能增加到具有统计学意义的水平(β= +0.58 pg/mL, p = 0.68)。

研究结果表明,正常肾功人群,使用TZ会降低PTH水平,而使用LD和二氢吡啶类CCB会增高PTH水平。这些联系或许可以解释使用这些药物与骨骼结局的关系。

原始出处:

Zaheer S,de Boer I,et al.Parathyroid Hormone and the Use of Diuretics and Calcium-Channel Blockers: The Multi-Ethnic Study of Atherosclerosis.J Bone Miner Res 2016 Jan 8;[Epub ahead of print]

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-12-03 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-10-24 lujian
  3. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-03-23 dhzzm

    学习了,很好

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-03-21 Gsurgeon

    我是甲状腺外科的对我很有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-03-21 milkshark

    的确这样

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]
    2016-03-21 1de304d2m86(暂无匿称)

    受教了,很好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1915135, encodeId=334619151354c, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 03 07:00:00 CST 2016, time=2016-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024119, encodeId=60792024119c7, content=<a href='/topic/show?id=2d551484e95' target=_blank style='color:#2F92EE;'>#PTH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14847, encryptionId=2d551484e95, topicName=PTH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Mon Oct 24 15:00:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73023, encodeId=97e9e3023ad, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:43:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72480, encodeId=a600e248088, content=我是甲状腺外科的对我很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:42:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72449, encodeId=5449e244946, content=的确这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Mar 21 21:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72111, encodeId=020ae2111a9, content=受教了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=218, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Mon Mar 21 13:28:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291863, encodeId=4b5612918637b, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Mar 21 13:00:00 CST 2016, time=2016-03-21, status=1, ipAttribution=)]