Neurol Clin Pract:外科手术可增加Guillain Barré综合症的发病率

2016-11-26 MedSci MedSci原创

Guillain Barré综合症(GBS)是一种罕见的自身免疫性疾病——攻击自身神经系统导致肌肉无力,严重情况下课导致瘫痪。目前关GBS的病因尚未清楚,来自梅奥诊所的一项新的研究表明,外科手术或可促进其发生,该研究结果已发表于Neurology Clinical Practice。美国神经病学学会(AAN)指出手术或可偶然引发GBS的发生。然而,新的研究表明近期行手术治疗的患者中,GBS的发病率

Guillain Barré综合症(GBS)是一种罕见的自身免疫性疾病——攻击自身神经系统导致肌肉无力,严重情况下课导致瘫痪。目前关GBS的病因尚未清楚,来自梅奥诊所的一项新的研究表明,外科手术或可促进其发生,该研究结果已发表于Neurology Clinical Practice。

美国神经病学学会(AAN)指出手术或可偶然引发GBS的发生。然而,新的研究表明近期行手术治疗的患者中,GBS的发病率或较以往所认为的高。

该新的研究中,研究人员探究了8周内接受手术与GBS发生的临床关联。研究人员回顾了1995年1月至2014年6月之间在梅奥诊所接受GBS治疗2年以上的患者的病历。结果共纳入了208例GBS患者,平均年龄55岁。

大多数患者所接受的手术是胃肠道、心脏或整形外科手术。58%的患者使用了全身麻醉,其余的患者则使用了镇静。

结果发现,15%的GBS患者在发病前2个月内接受了外科手术。208名GBS患者中,31名患者是在术后8周内发生GBS。

术后发生GBS的患者平均年龄为63岁,其中65%为男性。
GBS发病前6个月患有癌症的患者术后发生GBS的几率较非癌症患者高7倍。

存在自身免疫性疾病的患者也更容易发展为GBS。与无自身免疫性疾病的患者相比,溃疡性结肠炎或1型糖尿病患者术后发生GBS的几率高5倍。

术后发生GBS的31名患者中,19名(61%)患者为癌症患者和9名(29%)患者存在自身免疫性疾病。

最后,研究人员强调手术过程的安全性,术后GBS的发病率较低。

原始出处:

Sara Hocker et al., Guillain-Barré syndrome after surgical procedures, Neurology Clinical Practice. 23 November 2016. 


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content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-12-13 虈亣靌

    这个不错,学习了

    0

  4. 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content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-12-02 虈亣靌

    讲的好,学习了

    0

  5. 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content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-28 李东泽

    很好,不错,以后会多学习

    0

  6. 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encodeId=9e3c158385c0, content=学习了呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sun Nov 27 00:38:36 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158276, encodeId=22841582e6ac, content=学习了!谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C21FB043B43819A7B3317EFD10D7F21F/100, createdBy=4b831734815, createdName=QQa1c6be9c, createdTime=Sat Nov 26 12:42:21 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158239, encodeId=b9e11582395b, content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 老段

    …学习了,赞一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1999781, encodeId=a14e1999e812e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 17 04:06:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823298, encodeId=fae2182329833, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Oct 04 09:06:00 CST 2017, time=2017-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162476, encodeId=70231624e64c, content=这个不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Dec 13 13:13:47 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=159689, encodeId=88ef1596896e, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 02 13:32:03 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158711, encodeId=65eb158e11e0, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Nov 28 15:43:14 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343299, encodeId=622b1343299fe, content=<a href='/topic/show?id=d3ea4293676' target=_blank style='color:#2F92EE;'>#外科手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Nov 27 15:06:00 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158411, encodeId=1a231584118d, content=…学习了,赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 27 07:34:42 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158385, encodeId=9e3c158385c0, content=学习了呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sun Nov 27 00:38:36 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158276, encodeId=22841582e6ac, content=学习了!谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C21FB043B43819A7B3317EFD10D7F21F/100, createdBy=4b831734815, createdName=QQa1c6be9c, createdTime=Sat Nov 26 12:42:21 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158239, encodeId=b9e11582395b, content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 小树

    学习了呀

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1999781, encodeId=a14e1999e812e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 17 04:06:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823298, encodeId=fae2182329833, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Wed Oct 04 09:06:00 CST 2017, time=2017-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162476, encodeId=70231624e64c, content=这个不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Dec 13 13:13:47 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=159689, encodeId=88ef1596896e, content=讲的好,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Nov 27 15:06:00 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158411, encodeId=1a231584118d, content=…学习了,赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 27 07:34:42 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158385, encodeId=9e3c158385c0, content=学习了呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sun Nov 27 00:38:36 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158276, encodeId=22841582e6ac, content=学习了!谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C21FB043B43819A7B3317EFD10D7F21F/100, createdBy=4b831734815, createdName=QQa1c6be9c, createdTime=Sat Nov 26 12:42:21 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158239, encodeId=b9e11582395b, content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 QQa1c6be9c

    学习了!谢谢

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1999781, encodeId=a14e1999e812e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 17 04:06:00 CST 2017, time=2017-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823298, encodeId=fae2182329833, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42936, encryptionId=d3ea4293676, topicName=外科手术)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Nov 27 15:06:00 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158411, encodeId=1a231584118d, content=…学习了,赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 27 07:34:42 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158385, encodeId=9e3c158385c0, content=学习了呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sun Nov 27 00:38:36 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158276, encodeId=22841582e6ac, content=学习了!谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C21FB043B43819A7B3317EFD10D7F21F/100, createdBy=4b831734815, createdName=QQa1c6be9c, createdTime=Sat Nov 26 12:42:21 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158239, encodeId=b9e11582395b, content=指南指的好,工作脾气小, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Nov 26 09:35:38 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 李东泽

    指南指的好,工作脾气小

    0

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