大型前瞻性研究表明过量饮用咖啡或导致脑容量降低和痴呆症风险增加,喝到第几杯该停止?

2021-07-26 JACKZHAO MedSci原创

较高的咖啡摄入量与脑容量减少显著相关,与每天喝1-2杯咖啡的人相比,每天喝超过 6 杯咖啡,患痴呆症的风险增加了53%。

A cup of coffee a day might decrease the risk of heart failure صيدلية  جاردينيا

7月24日,据南澳大利亚大学的研究人员在 Nutritional Neuroscience 发表了一项关于咖啡的新研究表明,如果过量饮用可能会对大脑健康产生风险。其数据结论显示,较高的咖啡摄入量与脑容量减少显著相关,与每天喝1-2杯咖啡的人相比,每天喝超过 6 杯咖啡,患痴呆症的风险增加了53%。该研究是迄今为止对这一特定主题进行的在过去的基础上的最大规模研究,将定期饮用咖啡因与大脑萎缩联系起来。

Kitty Pham, Anwar Mulugeta, Ang Zhou, John T. O’Brien, David J. Llewellyn & Elina Hyppönen (2021) High coffee consumption, brain volume and risk of dementia and stroke, Nutritional Neuroscience, DOI: 10.1080/1028415X.2021.1945858

研究对 398,646 名英国生物银行参与者(37-73 岁)的习惯性咖啡消费进行了前瞻性分析,其中包括 17,702 名具有 MRI 信息的参与者。 使用协变量调整线性回归检查了与脑容量的关联,并使用逻辑回归检查了痴呆(4,333 例事件)和中风(6,181 例事件)的几率。

 

该研究的首席研究员Kitty Pham解释说,过量饮用咖啡和对大脑健康的负面影响之间的联系是有足够证据支撑的。

考虑到所有可能的变化,我们一致发现,较高的咖啡消费与脑容量的减少有明显的联系,基本上,每天喝超过六杯咖啡可能会使人面临痴呆症和中风等脑部疾病的风险。

痴呆症是一种退化的大脑疾病,会影响记忆、思维、行为和执行日常任务的能力。 全世界约有 5000 万人被诊断出患有该综合征。 在澳大利亚,痴呆症是第二大死因,估计每天有 250 人被确诊。

中风是大脑血液供应中断的一种情况,导致缺氧、脑损伤和功能丧失。 在全球范围内,四分之一的 25 岁以上成年人会在一生中中风。 数据显示,今年将有 1370 万人中风,其中 550 万人因此死亡。

研究人员说,他们不确定将过多的咖啡与大脑健康问题联系起来的"确切机制",但他们确实注意到,在消费方面找到正确的平衡可能有助于防止今后出现非常有害的大脑健康问题。

鉴于咖啡在世界各地的流行,这些发现令人不安。幸运的是,许多人每天喝的咖啡远远少于六杯,通常只坚持在早晨起床时喝一两杯。研究人员建议,根据他们的发现,那些发现自己喜欢喝特别多的饮料的人应该适当控制一下自己。

南澳大学澳大利亚精准健康中心的高级研究员兼主任 Elina Hyppönen 教授说,虽然这个消息对咖啡爱好者来说可能是苦涩的,但这一切都是为了在你喝的东西和对你的健康有益的东西之间找到平衡。“这项研究提供了关于大量咖啡消费和大脑健康的重要见解,但与生活中的许多事情一样,适度是关键,”Hyppönen 教授说。

“连同其他遗传证据和随机对照试验,这些数据强烈表明,大量饮用咖啡会对大脑健康产生不利影响。虽然确切的机制尚不清楚,但我们可以做的一件简单的事情就是保持水分,并记得在喝那杯咖啡的同时喝一点水。典型的日常咖啡消费量介于一到两杯标准咖啡之间。当然,虽然单位措施可能会有所不同,但每天喝几杯咖啡通常是可以的。

但是,如果您发现每天的咖啡消费量超过 6 杯,那么您是时候重新考虑下一杯喝什么了。

 

参考资料:Kitty Pham, Anwar Mulugeta, Ang Zhou, John T. O’Brien, David J. Llewellyn & Elina Hyppönen (2021) High coffee consumption, brain volume and risk of dementia and stroke, Nutritional Neuroscience, DOI: 10.1080/1028415X.2021.1945858

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    2021-07-28 aids218
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    2021-07-26 junJUN

    老年人痴呆何药可用??

    0

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    2021-07-26 pearcui1995

    有意思

    0