BMJ:不孕、复发性流产以及反复死产女性需警惕中风风险

2022-06-29 zhangfan MedSci原创

不孕、复发性流产以及反复死产女性人群的中风风险增加,这一发现有助于实现女性高风险人群的中风监测和积极预防。

全球范围内,中风是导致女性死亡和残疾的主要原因。2019年,约有300万女性死于中风,比男性高44%。中风的常见危险因素,如肥胖、高血压和糖尿病,都不足以解释中风风险的性别差异。近日研究人员考察了女性生育相关因素,如不孕症、复发性流产、死产对女性中风风险的影响。

InterLACE研究,包含来自7个国家,618851名基线年龄在32.0-73.0岁之间的女性,有相关的不孕、流产或死产及中风资料。研究的主要终点是非致命性中风事件以及中风死亡。

非致命性中风研究随访13.0年,中风死亡研究随访9.4年。研究期间,9265名(2.8%)女性经历了首次非致命性中风事件,4003名(0.7%)女性中风死亡。对患者高血压、种族、体重指数、吸烟状况、教育水平因素进行调整后,不孕与非致命性卒中风险增加相关(危险比1.14)。复发性流产(至少三次)与非致命性中风和中风死亡风险相关(HR=1.35和1.82)。死产女性的非致命性中风的风险高31%(HR=1.31),复发性死产女性的中风死亡风险高26%(1.26)。与不孕症或复发性死产相关的卒中(非致命性或致命性)风险增加主要由缺血性中风导致的。

女性生育因素与中风风险

研究发现,不孕、复发性流产以及反复死产女性人群的中风风险增加,这一发现有助于实现女性高风险人群的中风监测和积极预防

 

原始出处:

Chen Liang et al.Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women. BMJ,22 June 2022.

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    2022-11-05 gaoxiaoe
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