乳腺癌患者福音!两种免疫疗法药物结合法抗癌效果倍增!

2017-06-08 佚名 medicalxpress

【新疗法为乳腺癌患者带来新希望】墨尔本沃尔特癌症研究中心的研究人员发现一张免疫新疗法,用来治疗进阶性乳腺癌,研究人员表示,此次研究,他们将两种免疫疗法的药物相结合,用来治疗发生BRCA1突变的三阴性乳腺癌。

【新疗法为乳腺癌患者带来新希望】墨尔本沃尔特癌症研究中心的研究人员发现一张免疫新疗法,用来治疗进阶性乳腺癌,研究人员表示,此次研究,他们将两种免疫疗法的药物相结合,用来治疗发生BRCA1突变的三阴性乳腺癌。

免疫疗法是通过提高人体免疫细胞攻击肿瘤能力来对抗癌症,近些年来,一直是治疗黑色素瘤和肺癌的新疗法。

在澳大利亚,乳腺癌影响着八分之一的女性,其中三阴性乳腺癌通常约占乳腺癌总人数的15%,每年新增病例达到2400例,BRCA1突变的亚型最为常见。而且,研究人员表示,BRCA1突变的三阴性乳腺癌的发展速度和复发性更快。

研究人员说道:“在此前的治疗过程中,相对于其他癌症,靶向疗法对三阴性乳腺癌的治疗没有什么积极进展,而我们的研究表明,将化疗与抗PD1 和CTLA4免疫疗法相结合,可以阻止BRCA1突变有关的肿瘤生长,在实验室实验中取得了圆满成功。”

研究人员补充说:“一些癌细胞的存在劫持和“关闭”了有可能破坏肿瘤的免疫细胞。抗PD1和抗CTLA4免疫疗法是所谓的“免疫抑制剂检查站”,助力免疫细胞攻击肿瘤。以前的研究已经表明,免疫疗法治疗多种基因突变引起的肿瘤是非常有效的,BRCA1突变三阴性乳腺癌拥有一些最混乱的基因组,我们看到许多免疫细胞聚集在肿瘤附近,这就表示,免疫细胞的直觉是非常敏锐的,只是被肿瘤细胞禁锢了它们的能力,因此,我们通过使用抗PD1 和CTLA4相结合的免疫疗法帮它们恢复攻击肿瘤的能力,将细胞一网打尽。”

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    2017-06-13 laymankey

    感谢分享一下!

    0

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    2017-06-08 lovetcm

    各种不同免疫治疗组合是研究新方向

    0

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    2017-06-08 daiyaozu

    学习了,不错

    0

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    2017-06-08 wxl882001

    学习一下

    0

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    2017-06-08 飘飘爱

    很好

    0

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