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Clinica Chimica Acta：多囊卵巢综合征相关的代谢改变----基于UPLC Q-Exactive的代谢组学研究

2020-04-12 MedSci原创 MedSci原创

多囊卵巢综合征相关；代谢改变
关注

多囊卵巢综合征(PCOS)是育龄期女性最常见的内分泌代谢紊乱综合征。卵泡液的代谢组学研究可以揭示与多囊卵巢综合征相关的潜在代谢途径。本研究的目的是探讨多囊卵巢综合征患者卵泡液中代谢物的变化。

多囊卵巢综合征(PCOS)是育龄期女性最常见的内分泌代谢紊乱综合征。卵泡液的代谢组学研究可以揭示与多囊卵巢综合征相关的潜在代谢途径。本研究的目的是探讨多囊卵巢综合征患者卵泡液中代谢物的变化。

研究人员收集了35例PCOS患者和33例未患PCOS的对照组卵泡液样本，用UPLC Q-Exactive进行代谢组学分析。用KEGG和HMDB对鉴定的代谢物进行注释，以确定PCOS中代谢途径的干扰。基于回归模型，我们进行ROC分析，寻找卵泡液中PCOS的biomarker。

代谢组学分析发现PCOS中存在21种不同的代谢物，其中维生素B6代谢、苯丙氨酸代谢和肉碱合成是其主要的代谢改变途径。基于ROC分析，我们发现7β-hydroxycholesterol PCOS的潜在生物标志物。

本研究发现了多囊卵巢综合征滤泡液中的代谢改变和生物标志物，为多囊卵巢综合征的诊断和治疗提供了新的方法。

原始出处：

Xiaojiao Chen，Ting Lu，Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1718420, encodeId=504a1e18420e7, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Mon Apr 13 13:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779001, encodeId=c54b1e79001ae, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Wed Oct 21 15:46:29 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849897, encodeId=a0af184989ef6, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jul 01 17:46:29 CST 2020, time=2020-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804802, encodeId=64231804802c6, content=<a href='/topic/show?id=c4bee764836' target=_blank style='color:#2F92EE;'>#组学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77648, encryptionId=c4bee764836, topicName=组学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Dec 31 16:46:29 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431813, encodeId=b1c514318134d, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480309, encodeId=531014803095d, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050721, encodeId=e1491050e2192, content=代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Apr 13 00:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-13 kalseyzl

    #多囊卵巢#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1718420, encodeId=504a1e18420e7, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Mon Apr 13 13:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779001, encodeId=c54b1e79001ae, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Wed Oct 21 15:46:29 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849897, encodeId=a0af184989ef6, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jul 01 17:46:29 CST 2020, time=2020-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804802, encodeId=64231804802c6, content=<a href='/topic/show?id=c4bee764836' target=_blank style='color:#2F92EE;'>#组学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77648, encryptionId=c4bee764836, topicName=组学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Dec 31 16:46:29 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431813, encodeId=b1c514318134d, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480309, encodeId=531014803095d, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050721, encodeId=e1491050e2192, content=代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Apr 13 00:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-10-21 zhzhxiang

    #active#

    0

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    2020-07-01 windight

    #CTA#

    0

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    2020-12-31 xuyu

    #组学研究#

    0

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    2020-04-14 zhouqu_8

    #综合征#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1718420, encodeId=504a1e18420e7, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Mon Apr 13 13:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779001, encodeId=c54b1e79001ae, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Wed Oct 21 15:46:29 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849897, encodeId=a0af184989ef6, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jul 01 17:46:29 CST 2020, time=2020-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804802, encodeId=64231804802c6, content=<a href='/topic/show?id=c4bee764836' target=_blank style='color:#2F92EE;'>#组学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77648, encryptionId=c4bee764836, topicName=组学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Thu Dec 31 16:46:29 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431813, encodeId=b1c514318134d, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480309, encodeId=531014803095d, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Tue Apr 14 12:46:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050721, encodeId=e1491050e2192, content=代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Mon Apr 13 00:46:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-14 ms6897892027066920

    #代谢组#

    0

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    2020-04-13 明天jing

    代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。

    0