JAHA:伴有COVID-19的糖尿病患者服用他汀类药物与住院死亡率的关系

2020-10-24 MedSci原创 MedSci原创

服用他汀类药物可降低糖尿病患者因COVID-19导致的院内死亡率。如果证实这些结果,则可能会进一步突出在COVID-19期间对糖尿病患者使用他汀类药物的重要性。

严重的冠状病毒病(COVID-19)特征是炎症状态,伴有高死亡率。他汀类药物具有抗炎作用,并可能减弱COVID-19的严重程度。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究是对2020年3月1日至2020年5月2日期间连续入院的COVID-19成年患者进行的观察性研究。研究人员将患者分为接受和未接受他汀类药物组,并通过竞争事件回归法比较两组院内死亡率。此外,在生存模型中使用倾向得分匹配和逆概率治疗加权(IPTW)来评估他汀类药物使用与住院期间死亡之间的关联。

该研究共纳入4252例COVID-19患者。糖尿病改变了他汀类药物的使用与住院死亡率之间的关联。与未使用他汀类药物的患者相比,接受他汀类药物治疗的糖尿病患者(n=983)年龄较大(69±11 vs. 67±14岁,p<0.01),炎性标志物较低(C反应蛋白:10.2,IQR:4.5-18.4 vs. 12.9, IQR:5.9-21.4 mg/dl,p<0.01),住院时累计死亡率降低(24% vs. 39%,p<0.01)(n=1283)。没有接受他汀类药物治疗或未接受他汀类药物治疗的无糖尿病患者的住院死亡率没有差异(20% vs. 21%,p=0.82)。倾向评分匹配(HR=0.88,95%CI为0.83-0.94,p<0.01)和IPTW(HR=0.88,95%CI为0.84-0.92,p<0.01)发现相比于未接受他汀类药物治疗者,他汀类治疗者住院期间死亡风险降低12%。

由此可见,服用他汀类药物可降低糖尿病患者因COVID-19导致的院内死亡率。如果证实这些结果,则可能会进一步突出在COVID-19期间对糖尿病患者使用他汀类药物的重要性。

原始出处:

Omar Saeed.et al.Statin Use and In‐Hospital Mortality in Diabetics with COVID‐19.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/abs/10.1161/JAHA.120.018475

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    2020-10-25 taken110

    关于covid的研究越来越多

    0

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    2020-10-24 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-10-24 ms1000000260129966

    学习了

    0

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