一文介绍肿瘤标记物的检测、分布及临床常用的标记物和代谢产物

2018-10-15 佚名 检验医学网 医学之声

以下盘点了最常见的肿瘤标志物相关知识。

以下盘点了最常见的肿瘤标志物相关知识。



肿瘤标志物(TM)的检测意义重大,概括如下:

一、肿瘤筛查

肿瘤筛查就是从无症状人群中寻找可疑者。肿瘤标志物检测是肿瘤初筛的有效方法。常用于高危人群筛查。

AFP:筛查原发性肝癌。

PSA:50岁以上男性筛查前列腺癌。

高危型HPV :筛查宫颈癌。

CA125+超声:50岁以上妇女筛查卵巢癌

肿瘤标志物异常升高,无明显症状和体征,需进行复查、随访。如持续增高,应及时确诊。

二、诊断

辅助诊断:肿瘤标志物的特异性不够强,不能单纯依据肿瘤标志物确诊肿瘤,但可提供进一步诊断线索。

鉴别诊断:本-周氏蛋白、AFP、HCG、PSA等具有特征性癌谱。

不能定位诊断:肿瘤标志物缺乏组织器官特异性。

动态观察:肿瘤标志物进行性升高具有明确诊断意义;良性疾病的标志物升高为一过性;

恶性肿瘤的标志物升高为持续性。

三、监测病情和疗效

监测疗效、复发转移是肿瘤标志物最重要的临床应用。

肿瘤患者经手术,化疗或放疗后,特定的肿瘤标志物含量升降与疗效有良好的相关性,通过动态观察可反映肿瘤有无复发、转移。


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1904515, encodeId=a18b1904515a8, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Dec 13 11:59:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1931826, encodeId=86b219318268b, content=<a href='/topic/show?id=7b6c829e4b8' target=_blank style='color:#2F92EE;'>#肿瘤标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82974, encryptionId=7b6c829e4b8, topicName=肿瘤标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 11 04:59:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513455, encodeId=58d7151345561, content=<a href='/topic/show?id=8e4b2540671' target=_blank style='color:#2F92EE;'>#代谢产物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25406, encryptionId=8e4b2540671, topicName=代谢产物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e1510553828, createdName=124987c6m39暂无昵称, createdTime=Wed Oct 17 09:59:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349515, encodeId=0f633495157f, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Oct 16 10:45:08 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1904515, encodeId=a18b1904515a8, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Dec 13 11:59:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1931826, encodeId=86b219318268b, content=<a href='/topic/show?id=7b6c829e4b8' target=_blank style='color:#2F92EE;'>#肿瘤标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82974, encryptionId=7b6c829e4b8, topicName=肿瘤标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 11 04:59:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513455, encodeId=58d7151345561, content=<a href='/topic/show?id=8e4b2540671' target=_blank style='color:#2F92EE;'>#代谢产物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25406, encryptionId=8e4b2540671, topicName=代谢产物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e1510553828, createdName=124987c6m39暂无昵称, createdTime=Wed Oct 17 09:59:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349515, encodeId=0f633495157f, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Oct 16 10:45:08 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1904515, encodeId=a18b1904515a8, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Dec 13 11:59:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1931826, encodeId=86b219318268b, content=<a href='/topic/show?id=7b6c829e4b8' target=_blank style='color:#2F92EE;'>#肿瘤标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82974, encryptionId=7b6c829e4b8, topicName=肿瘤标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 11 04:59:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513455, encodeId=58d7151345561, content=<a href='/topic/show?id=8e4b2540671' target=_blank style='color:#2F92EE;'>#代谢产物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25406, encryptionId=8e4b2540671, topicName=代谢产物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e1510553828, createdName=124987c6m39暂无昵称, createdTime=Wed Oct 17 09:59:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349515, encodeId=0f633495157f, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Oct 16 10:45:08 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1904515, encodeId=a18b1904515a8, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Dec 13 11:59:00 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1931826, encodeId=86b219318268b, content=<a href='/topic/show?id=7b6c829e4b8' target=_blank style='color:#2F92EE;'>#肿瘤标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82974, encryptionId=7b6c829e4b8, topicName=肿瘤标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 11 04:59:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513455, encodeId=58d7151345561, content=<a href='/topic/show?id=8e4b2540671' target=_blank style='color:#2F92EE;'>#代谢产物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25406, encryptionId=8e4b2540671, topicName=代谢产物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e1510553828, createdName=124987c6m39暂无昵称, createdTime=Wed Oct 17 09:59:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349515, encodeId=0f633495157f, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Oct 16 10:45:08 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-16 kafei

    学习了谢谢

    0

相关资讯

全国肿瘤防治宣传周:滴血查癌到底靠不靠谱?

今年的4月15日至21日是第22届全国肿瘤防治宣传周,今年宣传周的主题为“科学抗癌,关爱生命”。去医院体检,不少人都会抽血查肝功能、血常规,如果说只要一滴血就能查出无患癌症风险,你信吗?当前,就偏偏有这样一些机构宣称“一滴血可查是否患癌症”,部分体检机构也声称一滴血或者几滴血便可以确诊癌症。专家表示,这并非是确诊癌症的根本标准。“一滴血查癌症”是检测肿瘤血清标记物抽血化验是体检和到医院就诊时经常做

肝癌早期诊出率低,高敏感肿瘤标记物有待发掘

肝炎离肝癌到底有多远?肝炎“入侵”,是不是一定会导致癌变?肝炎患者又应该如何“攻防”,保护肝脏“堡垒”的正常运转?首先要说明的是,肝炎虽然并不是导致肝脏癌变的直接“元凶”,但是肝炎、或者是肝炎导致的肝硬化,会让肝脏成为一座“危城”,稍有不慎就会被癌细胞“攻陷”。流行病学数据显示,具有乙肝或丙肝感染、肝硬化、肝癌家族史的人群,肝癌的发病率远比其他人群高。在诸多临床病史资料中,也会发现很多肝癌患者的病

华裔专家张锋研发“基因试纸” 检出肺癌患者肿瘤标记物

华裔专家张锋团队开发出一种“基因试纸”,可在实验室中成功检测出一些病毒感染及肺癌患者的肿瘤标记物。

Gut:OCT1基因与胃癌的关联

近日,上海交通大学医学院附属仁济医院消化科、上海市消化疾病研究所的研究团队发现了OCT1基因在胃癌发生和发展过程中的重要作用,研究提示OCT1基因通过激活而作用于ERK/MAPK信号通路,并使胃癌患者的生存显著缩短。相关论文4月9日在线发表于《消化道》(Gut)杂志。 OCT1与胃癌:多潜能诱导因子OCT4的家族基因在癌症中扮演重要作用 OCT1 是细胞多潜能性诱导因子OCT4的家族

肿瘤标志物在消化道肿瘤性疾病诊疗中的临床价值

日前,在北京举办的“2017罗氏肿瘤标志物专家研讨会”上,北京大学肿瘤医院消化肿瘤内科专家张晓东教授就肿瘤标志物在消化道肿瘤性疾病诊疗中的临床价值以及肿瘤标志物检测结果的合理解读进行了分享。肿瘤标志物检测的规范化管理及对检测结果的合理解读有助于临床获取更有价值的医学信息以改善临床决策,继而优化诊疗质量。

2016年肿瘤标记物研究进展

肿瘤标记物是指肿瘤细胞生物化学性质改变及代谢异常导致肿瘤病人的体液、排泄物及组织中出现的数量或者种类显著改变的物质,其在原发瘤诊断、肿瘤恶性程度诊断、肿瘤发展进程诊断、肿瘤治疗效果监控、肿瘤高危人群的筛选及肿瘤复发、预后等的预测方面具有至关重要的作用。小编于此盘点了2016年肿瘤标记物方面的重要研究成果,与大家一起学习讨论。 1、Cancer Res:雄性特有的前列腺癌诊断治