Diabetes Care:糖化血红蛋白低水平或预测普通人群死亡

2012-08-07 高晓方译 医学论坛网

  美国学者的一项研究表明,在普通人群中,糖化血红蛋白(HbA1c)低水平可能为死亡风险的泛化标志物。论文于2012年7月30日在线发表于《糖尿病护理》(Diabetes Care)杂志。    此项前瞻性队列研究共纳入13288例受试者。利用Logistic回归分析确认低HbA1c(<5%)的横断面相关性,并利用Cox比例风险模型评估低HbA1c与死因别死亡率的相关性。   结果显示,

  美国学者的一项研究表明,在普通人群中,糖化血红蛋白(HbA1c)低水平可能为死亡风险的泛化标志物。论文于2012年7月30日在线发表于《糖尿病护理》(Diabetes Care)杂志。

   此项前瞻性队列研究共纳入13288例受试者。利用Logistic回归分析确认低HbA1c(<5%)的横断面相关性,并利用Cox比例风险模型评估低HbA1c与死因别死亡率的相关性。

  结果显示,与HbA1c处于正常范围的受试者相比,低HbA1c者较为年轻,吸烟可能性较低,体质指数(BMI)、白细胞计数和纤维蛋白原水平较低,并且高胆固醇血症患病率以及冠心病既往患病率较低。然而,低HbA1c者贫血可能性较高,并且平均红细胞压积较高。在以HbA1c为5.0~5.7为参照组的校正Cox模型中,HbA1c<5.0%与全因死亡(危险比[HR] 1.32)和癌症死亡(HR 1.47)风险显著升高具有相关性;心血管性和呼吸系统性死亡风险具有非显著升高趋势。HbA1c与肝脏疾病住院之间呈J形相关。

  链接:

  Low Hemoglobin A1c in Nondiabetic Adults

  An elevated risk state?



    

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