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Clinica Chimica Acta：血清N末端脑利钠肽、半乳糖蛋白酶-3对缺血性脑卒中1年后预后的联合影响

2021-01-04 MedSci原创 MedSci原创

血清；N末端脑利钠肽前
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N末端脑钠素前体肽（NT-proBNP）和半乳糖凝集素3是与缺血性卒中相关的重要生物标志物。但是，它们的组合的预测价值在先前的研究中尚未得到研究。

N末端脑钠素前体肽（NT-proBNP）和半乳糖凝集素3是与缺血性卒中相关的重要生物标志物。但是，它们的组合的预测价值在先前的研究中尚未得到研究。本研究旨在探讨NT-proBNP和半乳糖蛋白酶-3联合应用对缺血性脑卒中患者临床结局的影响。

这项研究共纳入了2694例同时测量血清NT-proBNP和galectin-3的患者（男性为63.62％；入院平均年龄= 62.4）。主要结果是卒中发作1年后死亡或严重残疾的综合结果。次要结局分别为死亡，严重残疾，血管事件以及血管事件或死亡的综合结果。根据NT-proBNP和galectin-3将参与者分为4组。计算奇数比（OR；无时间变量的非事件结果：主要结果，严重残疾）或危险比（HR；有时间变量的事件结果：死亡，血管事件以及血管事件或死亡的综合结果）进行评估NT-proBNP和galectin-3状态与不良结局的关系。

在1年的随访中，589名患者在中风发作后经历了主要结果。在调整潜在混杂因素后，高NT-ProBNP/高Galectin-3组与主要结果(OR：1.43；95%可信区间：1.0~2.00；P值=0.039)、死亡(HR：2.74；95%CI，1.42~5.29；P值=0.003)、血管事件或死亡的综合结果(HR：1.66；95%CI，1.0~2.58；P值=0.026)增加相关。4组间交互作用与主要结局或死亡的统计学检验均无显著性意义。

研究结果表明，同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。

原始出处：

Yang Liu，Daoxia Guo，Combined effect of serum N-terminal pro-brain natriuretic peptide and galectin-3 on prognosis 1 year after ischemic stroke

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    2021-02-12 windight

    #CTA#

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    2021-09-18 canlab

    #蛋白酶#

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    2021-11-14 ms7524819409032184

    #缺血性脑#

    0

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time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-05-08 guihongzh

    #缺血性#

    0

  5. 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content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627260, encodeId=3712162e26015, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-01-05 tonychen21

    #利钠肽#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1850085, encodeId=99ff1850085bd, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Feb 12 08:31:26 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945237, encodeId=67a9194523eed, content=<a href='/topic/show?id=249488e60fe' target=_blank style='color:#2F92EE;'>#蛋白酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88760, encryptionId=249488e60fe, topicName=蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, 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content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627260, encodeId=3712162e26015, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-01-05 minzju5058

    #乳糖#

    0

  7. 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content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627260, encodeId=3712162e26015, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-01-05 chentianping

    #糖蛋白#

    0

  8. 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createdName=canlab, createdTime=Sat Sep 18 17:31:26 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807150, encodeId=0de2180e1506b, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Nov 14 09:31:26 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893349, encodeId=4953189334921, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat May 08 09:31:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366491, encodeId=5d9d13664918e, content=<a href='/topic/show?id=76923233335' target=_blank style='color:#2F92EE;'>#利钠肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32333, encryptionId=76923233335, topicName=利钠肽)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac1c235, createdName=tonychen21, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588747, encodeId=7c4f1588e475a, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627260, encodeId=3712162e26015, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-01-04 Jessica

    同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。

    0

  9. 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createdName=canlab, createdTime=Sat Sep 18 17:31:26 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807150, encodeId=0de2180e1506b, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Nov 14 09:31:26 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893349, encodeId=4953189334921, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat May 08 09:31:26 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366491, encodeId=5d9d13664918e, content=<a href='/topic/show?id=76923233335' target=_blank style='color:#2F92EE;'>#利钠肽#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32333, encryptionId=76923233335, topicName=利钠肽)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac1c235, createdName=tonychen21, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588747, encodeId=7c4f1588e475a, content=<a href='/topic/show?id=8ac523668e8' target=_blank style='color:#2F92EE;'>#乳糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23668, encryptionId=8ac523668e8, topicName=乳糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a5a17619424, createdName=minzju5058, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627260, encodeId=3712162e26015, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Tue Jan 05 23:31:26 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913705, encodeId=4e57913e05c1, content=同时升高NT-proBNP和Galectin-3显著增加缺血性卒中后1年临床预后不良的风险。NT-proBNP和Galectin-3联合使用可准确预测缺血性卒中的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 21:00:11 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026740, encodeId=4e931026e4029, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 04 11:31:26 CST 2021, time=2021-01-04, status=1, ipAttribution=)]
    2021-01-04 健健

    卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

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