JACC:二尖瓣反流患者中的左室纤维化情况

2018-08-15 MedSci MedSci原创

近期有研究报道原发性二尖瓣反流(MR)患者的左室纤维化主要是由二尖瓣脱垂(MVP)导致。本研究的目的旨在通过心血管磁共振(CMR)评估MR伴有MVP或者不伴有MVP患者的左室纤维化的发生率、临床特征和预后。本研究对一个大型MR队列中的患者分成了MVP组和非MVP组,主要终点事件是心律失常事件(心源性死亡、心脏骤停和持续性或诱导性室性心律失常)。最终,本研究共纳入356名原发性MR患者,其中177名

近期有研究报道原发性二尖瓣反流(MR)患者的左室纤维化主要是由二尖瓣脱垂(MVP)导致。本研究的目的旨在通过血管磁共振(CMR)评估MR伴有MVP或者不伴有MVP患者的左室纤维化的发生率、临床特征和预后。

本研究对一个大型MR队列中的患者分成了MVP组和非MVP组,主要终点事件是心律失常事件(心源性死亡、心脏骤停和持续性或诱导性室性心律失常)。最终,本研究共纳入356名原发性MR患者,其中177名为MVP组,179名为非MVP组。与非MVP组患者相比,左室纤维化在MVP组更高(36.7% vs. 6.7%; p < 0.001),即使在经临床变量、心脏重塑评估和MR严重程度调整后分析,MVP也是与左室纤维化最相关的因子(OR:6.82; p < 0.001),经过平均1354天时间的随访,MVP组中患有左室纤维化的患者发生心律失常事件的风险最高。

本研究结果显示,在原发性二尖瓣反流患者中,左室纤维化的发生风险在有二尖瓣脱垂的患者中最高,且左室纤维化可作为心律失常事件发生的风险因子。

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    2018-12-23 hbwxf
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    2018-08-17 wwzzly
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    2018-08-16 wxl882001

    了解一下

    0

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    2018-08-16 1ddf0692m34(暂无匿称)

    学习了,长知识

    0

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    2018-08-15 清风拂面

    谢谢分享学习

    0

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