JCEM:妊娠早期甲状腺功能和TPOAb对妊娠结局的影响

2019-11-03 xing.T MedSci原创

由此可见,妊娠早期TSH为2.5-4.08 mIU/L联合TPOAb(-)与流产和孕产妇综合结局相关。在TSH为2.5-4.08 mIU/L的孕妇中使用L-T4的优缺点仍不确定。

TSH轻度升高(2.5-4.08 mIU/L)对妊娠结局的影响尚不清楚。根据指南,轻度TSH升高的治疗策略取决于TPOAb的状态。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估妊娠早期轻度甲状腺功能障碍合并TPOAb状态对妊娠结局的影响,以及L-T4治疗对妊娠结局的影响。

该研究回顾性地评估了3562名孕妇。共有3296名未接受治疗的妇女分为四个亚组:A组:4.08

A组流产和孕产妇综合结局风险分别高出3.53(1.85-6.75)和2.19(1.26-3.81)倍; C组比D组高1.58(1.17-2.13)和1.27(1.04-1.54)倍。与未治疗组相比,L-T4改善了TSH为4.08-10和2.5-4.08 mIU/L组患者的流产风险,但使TSH为2.5-4.08 mIU/L治疗组的妊娠期糖尿病风险增加了一倍。

由此可见,妊娠早期TSH为2.5-4.08 mIU/L联合TPOAb(-)与流产和孕产妇综合结局相关。在TSH为2.5-4.08 mIU/L的孕妇中使用L-T4的优缺点仍不确定。

原始出处:

Yang Zhang,et al.The impact of thyroid function and TPOAb in the first trimester on pregnancy outcomes: a retrospective study in Peking.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz167

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    2020-06-02 smallant2015
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    2019-11-13 achengzhao
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