BMC Gastroenterology: 老年人非酒精性脂肪性肝病的患病率和长期预后分析

2019-05-13 不详 MedSci原创

老年人非酒精性脂肪性肝病(NAFLD)的患病率以及远期预后并没有高质量的研究进行报道,因此,本项研究的目的是评估60岁以上人群中NAFLD的患病率,危险因素和死亡率。

背景
老年人非酒精性脂肪性肝病(NAFLD)的患病率以及远期预后并没有高质量的研究进行报道,因此,本项研究的目的是评估60岁以上人群中NAFLD的患病率,危险因素和死亡率。

方法
研究人员招募了一批在医院行健康体检的高领患者,在没有其他肝病原因的情况下,NAFLD由美国脂肪肝指数定义。Cox比例风险模型用于评估全因和血管(CV)死亡率。

结果
本项研究共纳入了三千二百七十一名患者。年龄在60-74岁和> 74岁之间的NAFLD的患病率为40.3%(95%CI:37.2-43.5%)和39.2%(95%CI:34.4-44.0%)。在60-74岁年龄段中,5年和10年全因死亡率的风险与NAFLD的存在相关[调整后的风险比:5年为1.60(95%CI:1.24-1.96)和10年为1.22(95% CI:1.01-1.49)]。该组的CV死亡率较高(5年为aHR:2.12(95%CI:1.20-3。75),10年为1.06(95%CI:0.73-1.52)。相比之下,> 74岁患者NAFLD的诊断与全因或CVD死亡率无关。

结论
NAFLD在老年人群中很常见。虽然NAFLD与60-74岁人群死亡风险增加有关,但74岁以上人群的这种风险并未增加。

原始出处:

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GetPortalCommentsPageByObjectIdResponse(id=1645607, encodeId=ab37164560ef4, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Mon Sep 23 05:50:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064712, encodeId=7a4b2064e1272, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Mar 04 13:50:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250621, encodeId=477d125062146, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed May 15 08:50:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2020-02-09 qjddjq
  5. 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  6. 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  7. 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createdBy=0bed488, createdName=jktdtl, createdTime=Wed Mar 04 13:50:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250621, encodeId=477d125062146, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed May 15 08:50:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2019-07-20 许安
  8. 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  9. 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  10. 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Clin Gastroenterology H:无症状青年结直肠肿瘤的患病率和危险因素分析

50岁以下的人群中结肠直肠癌的发病率正在逐年增加。然而,有关年轻发病性结直肠肿瘤(CRN)流行病学的数据很有限。虽然一些研究调查了CRN在50岁以下人群中的流行病学数据,但大多数研究都集中在40岁或以上的人群。因此,本项研究旨在评估40岁以下成人CRN的患病率和危险因素。