Caspian J Intern Med:与利多卡因单独静脉局部麻醉相比,利多卡因联合氨丁三醇有更好的麻醉镇痛效果

2018-02-14 王贵龙 “罂粟花”微信号

利多卡因联合氨丁三醇用于静脉局部麻醉有较好的镇痛效果。

背景与目的

静脉局部麻醉是上肢手术常用的简单且可靠的麻醉方式。为了增加麻醉效果与减轻疼痛,临床上已出现许多药物与利多卡因联合运用的方案,本研究探讨氨丁三醇与利多卡因联合使用的局部麻醉效果。

方  法

本研究纳入ASA分级I 或II级行择期上肢手术患者40例,随机分为了两组:一组(利多卡因组):20例患者均接受200mg利多卡因,二组(利多卡因联合氨丁三醇组):20例患者均接受200mg利多卡因+20mg氨丁三醇,两组患者用药均稀释为40ml;于术后1、6、12、24h进行各指标记录及VAS疼痛评分。

结  果

两组间松止血带时疼痛无统计学意义(P=0.443);利多卡因联合氨丁三醇组松止血带后疼痛发生时间较利多卡因组晚;利多卡因联合氨丁三醇组术后VAS评分明显低于利多卡因组,且利多卡因联合氨丁三醇组要求额外镇痛药物使用的患者数量较少(P<0.001)。

结  论

利多卡因联合氨丁三醇用于静脉局部麻醉有较好的镇痛效果。

原始出处:

Seyfi S, Banihashem N, Bijani A, et al. Analgesic effects of lidocaine-ketorolac compared to lidocaine alone for intravenous regional anesthesia. Caspian J Intern Med 2018; 9(1):32-37.

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    2019-01-10 fusion
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 zhaojie88
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 chg122
  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1822505, encodeId=25ed18225054f, content=<a href='/topic/show?id=bd3e10309e42' target=_blank style='color:#2F92EE;'>#麻醉镇痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103097, encryptionId=bd3e10309e42, topicName=麻醉镇痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Wed Jun 13 19:08:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697646, encodeId=e109169e64623, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 yaanren
  9. [GetPortalCommentsPageByObjectIdResponse(id=1822505, encodeId=25ed18225054f, content=<a href='/topic/show?id=bd3e10309e42' target=_blank style='color:#2F92EE;'>#麻醉镇痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103097, encryptionId=bd3e10309e42, topicName=麻醉镇痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Wed Jun 13 19:08:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697646, encodeId=e109169e64623, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287848, encodeId=c28a28e848c7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Feb 14 09:24:01 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 龙胆草

    学习谢谢分享

    0

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Clin oral invest:双颌手术后静脉注射利多卡因有利于疼痛缓解 这项前瞻性,随机,双盲,安慰剂对照研究的目的是评估静脉注射利多卡因对双颌手术后的镇痛

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J Pain Res:不同剂型及不同添加剂的局麻药效果

局部麻醉用于控制与许多程序相关的疼痛。现在最常用的局部麻醉是德国的EMLA(利多卡因/丙胺卡因)。然而,丙胺卡因是一种高铁血红蛋白诱导剂,使用具有局限性,尤其是在新生儿和婴儿中。本研究旨在评估丙胺卡因和利多卡因以及丙二醇(渗透促进剂)和氨丁三醇(缓冲物质)在麻醉剂中的应用效果。研究共纳入了29名健康成人,暴露于标准化疼痛刺激(钝/锋利0.2,0.4或0.8 N的压力)时,使用视觉模拟评分评估受试者

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关于利卡多因,其适应症:局麻药、抗心律失常药。主要用于局部浸润麻醉、硬膜外麻醉、表面麻醉、神经阻滞麻醉,可用于急性心肌梗塞后室性早搏和室性心动过速,也可用于洋地黄中毒、外科手术及心导管引起的室性心律失常。目前国内临床以普鲁卡因、丁卡因、利多卡因和布比卡因最常用。普鲁卡因首次应用一般要皮试,单一应用麻醉效果差,需加入肾上腺素,有高血压和心脏病者慎用。利多卡因自1954年起临床使用推广,现在已广泛

J Investig Clin Dent:牙科麻醉可乐定对利多卡因局麻的影响

局麻中利多卡因可以混合肾上腺素,肾上腺素可被可乐定所替代,此种替代在各种随机对照试验中进行了试验。因此,当前此系统评价的目的是收集利多卡因加可乐定行牙科麻醉的证据。