Can Med Assoc J:怀孕早期使用抗生素可能会导致流产风险翻倍

2017-05-01 tulip1999 来宝网

一项最新研究表明,怀孕早期抗生素使用指南可能需要进行重新审查,研究人员发现,一些常用药物可能会使流产的风险翻倍。

一项最新研究表明,怀孕早期抗生素使用指南可能需要进行重新审查,研究人员发现,一些常用药物可能会使流产的风险翻倍。

加拿大蒙特利尔大学的研究人员已经确定,妊娠早期使用大环内酯类、四环素类、喹诺酮类药物以及其他一些常见抗生素与流产风险增加有关。

这一最新研究成果发表在《加拿大医学协会杂志》上发表。

流产是指怀孕20周之前胎儿的自然丢失。

根据尤妮斯甘乃迪施莱佛儿童健康和人类发展国家研究所数据显示,知道自己怀孕的女性当中大约有15%-20%发生流产,最常见于35岁以上的孕妇。

超过半数以上流产是由于胎儿染色体异常引起的。其他可能会增加流产风险的因素还包括糖尿病、多囊卵巢综合征、肥胖和感染

该研究的合着者,蒙特利尔大学药学院的Anick Bérard博士指出,在怀孕期间常常会通过使用抗生素来帮助治疗感染,但评估其安全性的研究已经得出了相互矛盾的结果。

研究人员对1998-2009年魁北克妊娠人群数据进行了回顾,其中包括8,702名年龄在15岁至45岁,曾经在其妊娠平均14周左右发生过流产的人群。这些女性与87,020名正常孕妇进行对照。

结果确定,在妊娠早期使用过抗生素的女性当中有1,428例(16.4%)发生流产,而对照组只有1,018例(12.6%)。

研究人员发现,在怀孕早期使用某些抗生素会使流产风险增加两倍以上。

然而,研究人员说,他们无法排除感染严重程度也可能会导致流产的事实,这是该研究存在的一个明显的局限性。

尽管如此,他们认为该研究结果对早期妊娠使用抗生素的安全性提出了质疑。他们总结道:

“我们的研究结果可能或许有利于决策者对妊娠期间治疗感染的指南进行更新。”

原始出处:

Flory T. Muanda, et al.  Use of antibiotics during pregnancy and risk of spontaneous abortion.  CMAJ May 1, 2017 vol. 189 no. 17 doi: 10.1503/cmaj.161020

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    2017-05-03 1551ecd606m

    谢谢分享,,,,,

    0

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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 03 10:45:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193163, encodeId=3f4219316311, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Wed May 03 07:36:46 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193132, encodeId=c83019313291, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue May 02 11:22:51 CST 2017, time=2017-05-02, status=1, ipAttribution=)]
  5. 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GetPortalCommentsPageByObjectIdResponse(id=1394188, encodeId=9c501394188bb, content=<a href='/topic/show?id=1646452e771' target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Wed May 03 10:45:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607456, encodeId=0df0160e45637, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed May 03 06:46:30 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193009, encodeId=355119300909, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Tue May 02 23:16:27 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193004, encodeId=d0fc1930044c, content=哎,怀孕中最好能不用就不用药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Tue May 02 23:06:49 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192908, encodeId=2515192908c6, content=妊娠期慎用抗生素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue May 02 13:02:07 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192834, encodeId=632619283481, content=妊娠用药安全分级, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue May 02 11:22:51 CST 2017, time=2017-05-02, status=1, ipAttribution=)]
    2017-05-03 tofsw

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2076597, encodeId=d18020e6597ed, content=<a href='/topic/show?id=457c5211484' target=_blank style='color:#2F92EE;'>#怀孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52114, encryptionId=457c5211484, topicName=怀孕早期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Jan 01 22:45:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193414, encodeId=1bbd193414ca, content=谢谢分享,,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3092056006, createdName=1551ecd606m, createdTime=Wed May 03 22:34:43 CST 2017, time=2017-05-03, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed May 03 06:46:30 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193009, encodeId=355119300909, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Tue May 02 23:16:27 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193004, encodeId=d0fc1930044c, content=哎,怀孕中最好能不用就不用药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Tue May 02 23:06:49 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192908, encodeId=2515192908c6, content=妊娠期慎用抗生素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue May 02 13:02:07 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192834, encodeId=632619283481, content=妊娠用药安全分级, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue May 02 11:22:51 CST 2017, time=2017-05-02, status=1, ipAttribution=)]
    2017-05-03 龙胆草

    学习了,谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2076597, encodeId=d18020e6597ed, content=<a href='/topic/show?id=457c5211484' target=_blank style='color:#2F92EE;'>#怀孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52114, encryptionId=457c5211484, topicName=怀孕早期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Jan 01 22:45:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193414, encodeId=1bbd193414ca, content=谢谢分享,,,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3092056006, createdName=1551ecd606m, createdTime=Wed May 03 22:34:43 CST 2017, time=2017-05-03, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed May 03 06:46:30 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193009, encodeId=355119300909, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Tue May 02 23:16:27 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193004, encodeId=d0fc1930044c, content=哎,怀孕中最好能不用就不用药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue May 02 11:22:51 CST 2017, time=2017-05-02, status=1, ipAttribution=)]
    2017-05-02 lemon985

    学习

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue May 02 11:22:51 CST 2017, time=2017-05-02, status=1, ipAttribution=)]
    2017-05-02 林3301

    哎,怀孕中最好能不用就不用药物

    0

  9. 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    2017-05-02 1e0f8808m18(暂无匿称)

    妊娠期慎用抗生素。

    0

  10. 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    2017-05-02 cqykthl

    妊娠用药安全分级

    0

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