Hum Psychopharmacol:高剂量VitB6可能缓解焦虑和抑郁

2022-07-20 MedSci原创 MedSci原创

一项新的研究表明,服用高剂量维生素 B6 补充剂可能有助于减轻焦虑和抑郁的感觉。 来自英格兰雷丁大学的研究人员David Field 报告说,服用 50 倍于每日推荐剂量的年轻人报告说,一个

一项新的研究表明,服用高剂量维生素 B6 补充剂可能有助于减轻焦虑和抑郁的感觉。 来自英格兰雷丁大学的研究人员David Field 报告说,服用 50 倍于每日推荐剂量的年轻人报告说,一个月后焦虑和抑郁的感觉减轻了。这项研究结果发表在Human Psychopharmacology: Clinical and Experimental杂志上。

这是一项随机对照双盲的临床研究,调查了与安慰剂相比,补充高剂量 B6 或 B12 1 个月对与神经抑制和兴奋之间的平衡相关的一系列行为结果测量的影响。

在五个相关阶段共招募了 478 名年轻人。 在基线和补充后评估自我报告的焦虑(N = 265)和抑郁(N = 146)。 几种感官测量作为抑制功能的测定,仅在补充后进行评估; 这些是视觉对比度检测的环绕抑制 (N = 307)、双眼竞争逆转率 (N = 172) 和一系列触觉灵敏度测试 (N = 180)。

结果发现,维生素 B6 补充剂减少了自我报告的焦虑并诱导了减少抑郁的趋势,以及增加了视觉对比度检测的环绕抑制,但并没有可靠地影响其他结果测量。 维生素 B12 补充剂产生了焦虑和视觉处理变化的趋势。

什么是维生素B6?

维生素 B6 帮助身体将蛋白质和碳水化合物转化为能量,它在神经系统中也起着重要作用。它还增加了身体产生 GABA(γ-氨基丁酸)的化学物质,这种化学物质可以阻断大脑中神经细胞之间的冲动。维生素 B6 天然存在于各种食物中,包括鲑鱼、金枪鱼、鹰嘴豆和香蕉。

“大脑的功能依赖于携带信息的兴奋性神经元和防止失控活动的抑制性神经元之间的微妙平衡,”雷丁大学的David Field 博士在媒体发布中说。 “最近的理论将情绪障碍和其他一些神经精神疾病与这种平衡的紊乱联系起来,通常是在提高大脑活动水平的方向上。维生素 B6 帮助身体产生一种特定的化学信使,抑制大脑中的冲动,我们的研究将这种镇静作用与减少参与者的焦虑联系起来。”

该研究提供了以前研究中缺乏的证据来说明究竟是什么驱动了马麦和多种维生素的减压效果。

超过 300 名参与者以推荐量的 50 倍(约 70 毫克)服用安慰剂或维生素 B6 或 B12 补充剂。每个参与者每天服用一粒药片。与安慰剂相比,维生素 B12 几乎没有效果,但 B6 显示出统计学上可靠的差异。

服用过多有风险吗?

试验结束时的视觉测试证实了服用维生素 B6 的参与者的 GABA 水平升高,支持补充剂减少焦虑的假设。

该团队还检测到视觉表现的微妙但无害的变化,与大脑活动的受控水平一致。英国的卫生官员建议人们不要服用太高的剂量——每天超过 200 毫克——因为它会导致手臂和腿部失去知觉。在少数情况下,这对于服用了几个月非常大剂量的人来说已经成为永久性的。

“许多食物,包括金枪鱼、鹰嘴豆和许多水果和蔬菜,都含有维生素 B6。然而,该试验中使用的高剂量表明,补充剂对于对情绪产生积极影响是必要的,”菲尔德博士继续说道。 “重要的是要承认这项研究处于早期阶段,与您对药物的预期相比,我们研究中维生素 B6 对焦虑的影响非常小。然而,与药物相比,基于营养的干预措施产生的令人不快的副作用要少得多,因此未来人们可能更喜欢将它们作为干预措施。

研究作者总结道:“为了使这成为一个现实的选择,需要进一步研究以确定其他有益于心理健康的基于营养的干预措施,从而在未来将不同的饮食干预措施结合起来以提供更好的结果。” “一个潜在的选择是将维生素 B6 补充剂与认知行为疗法等谈话疗法相结合,以提高其效果。”

参考资料:

Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T.High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.Hum Psychopharmacol. 2022 Jul 19:e2852. doi: 10.1002/hup.2852

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    2023-05-03 amy0550
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    2023-01-18 yb6560
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SMI患者有更高的多发病负担,特别是在年轻的年龄组。