IJLH:cd56明亮自然杀伤细胞在重度再生障碍性贫血中表现出异常的表型和功能

2019-07-22 Gladiator MedSci原创

有研究表明cd56明亮NK细胞具有免疫调节功能。然而,它们在严重再生障碍性贫血(SAA)中的作用尚未阐明。 在此,研究人员研究了SAA、SAA缓解期(R‐SAA)和健康对照组(HC)患者外周血CD56bright NK细胞和CD56dim NK细胞的数量、表型、细胞因子分泌能力和细胞毒性。观察到SAA中cd56明亮NK细胞的数量较R‐SAA和HC减少。在SAA中,cd56明亮NK细胞的数量与

有研究表明cd56明亮NK细胞具有免疫调节功能。然而,它们在严重再生障碍性贫血(SAA)中的作用尚未阐明。

在此,研究人员研究了SAASAA缓解期(RSAA)和健康对照组(HC)患者外周血CD56bright NK细胞和CD56dim NK细胞的数量、表型、细胞因子分泌能力和细胞毒性。观察到SAAcd56明亮NK细胞的数量较RSAAHC减少。在SAA中,cd56明亮NK细胞的数量与疾病的严重程度相关。CD56bright NK细胞上的活化受体NKp46NKp44被上调,而抑制受体NKG2ASAA中被下调。 与从HC获得的细胞相比,从SAA患者获得的CD56bright NK细胞在体外促进IL-10和降低IFN-γ,而TNF-α和IL-13在两组之间没有差异。 在用IL-2IL-12进行的7天预刺激中,SAA患者的血清浓度较高,从HC获得的CD56bright NK也出现了IL-10mRNA增加。 SAAHCCD56bright NK细胞之间的细胞毒性没有差异。

本研究发现在SAA中,cd56明亮NK细胞表现出异常的受体表达和细胞因子的出现,且与病情的严重程度有关。

原始出处:

Tong Chen, ChunYan Liu, CD56 bright natural killer cells exhibit abnormal phenotype and function in severe aplastic anemia

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    2019-12-18 jklm09
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    2019-07-24 tastas

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