JAHA:重度主动脉瓣狭窄患者的猝死

2018-05-19 xiangting MedSci原创

无症状性重度AS患者的猝死发生率可能高于先前报道。几项基线临床和超声心动图特征与猝死风险升高相关。

据报道,无症状性重度主动脉瓣狭窄(AS)患者猝死的年发病率较低(<1%/年),并且关于重度AS患者猝死危险因素的数据很少。

当代重度主动脉瓣狭窄患者手术和内科治疗后的预后登记(CURRENT AS),于2003年至2011年间共纳入3815例连续性重度AS患者,研究人员评估了1334天的中位随访期内的猝死发病率和危险因素。患者平均年龄为78岁,男性占38%,既往心梗的患病率为8%。175例未接受主动脉瓣置换的患者猝死。作为竞争风险的主动脉瓣置换时的有症状患者猝死5年累积发生率为9.2%,无症状患者为7.2%(1.4%/年)(P<0.001)。在猝死的82例无症状患者中,54例(66%)突然死亡,没有任何先兆,35例(65%)在最后一次随访的3个月内猝死。猝死的独立危险因素为血液透析(风险比[HR] 3.63; 95%置信区间[CI] 2.42-5.43),既往心梗(HR 2.11; 95%CI 1.28-3.50),BMI<22(HR 1.51; 95%CI 1.03-2.21),主动脉搏动峰值速度≥5m/s(HR 1.76; 95%CI 1.12-2.78)和左室射血分数<60%(HR 1.52; 95%CI 1.08-2.14)。

无症状性重度AS患者的猝死发生率可能高于先前报道。几项基线临床和超声心动图特征与猝死风险升高相关。

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