Int Arch Allergy Immunol:在对屋尘螨敏感的儿童中,局部过敏性鼻炎流行度和临床特性分析

2017-11-30 AlexYang MedSci原创

局部过敏性鼻炎(LAR)在非遗传过敏性儿童中的流行度仍旧未知。最近,有研究人员在儿童群体中确定了LAR的流行度、临床特性和严重度,并与经典过敏性鼻炎(AR)和非过敏性鼻炎(NAR)进行了比较。研究总共包括了145名儿童(1-18岁),并且根据皮刺试验(SPT)和屋尘螨的鼻激发试验(NPT)结果被分为3个组(AR、NAR和LAR)。NPT阳性被定义为症状得分大于健康对照得分,并且不小于2个标准差(S

局部过敏性鼻炎(LAR)在非遗传过敏性儿童中的流行度仍旧未知。最近,有研究人员在儿童群体中确定了LAR的流行度、临床特性和严重度,并与经典过敏性鼻炎(AR)和非过敏性鼻炎(NAR)进行了比较。

研究总共包括了145名儿童(1-18岁),并且根据皮刺试验(SPT)和屋尘螨的鼻激发试验(NPT)结果被分为3个组(AR、NAR和LAR)。NPT阳性被定义为症状得分大于健康对照得分,并且不小于2个标准差(SDs)。研究发现,81名儿童患有AR(55.9%),64(44.1%)名儿童有鼻炎症状且SPT为阴性;并且鉴定出了59名NAR(40.7%)和5名LAR(3.4%)儿童。SPT和NPT之间的一致性κ 得分为0.778((95% CI 0.726-0.830, p < 0.001)。另外,研究人员在风团直径和由D.pteronyssinus激发的最大鼻症状得分之间发现了显著的相关性(rho=0.589,p<0.001)。而根据ARIA指南的鼻严重度在3个小组中都没有展现出任何的差异(p=0.693)。AR组要比LAR和NAR组年龄更大(AR>LAR>NAR,p=0.003)。最后,研究人员指出,尽管证据支持了LAR在儿科群体中的存在,研究人员发现它的流行度相对较低,很可能是因为SPT和NPT的高比例一致性。进一步的研究是需要的,从而鉴定LAR免疫学特性的和临床意义。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2046910, encodeId=bffd204691001, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Oct 15 01:59:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027796, encodeId=0021202e796a4, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Thu Jan 04 03:59:00 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044933, encodeId=6eba20449330c, content=<a href='/topic/show?id=3dd62288e2b' target=_blank style='color:#2F92EE;'>#临床特性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22887, encryptionId=3dd62288e2b, topicName=临床特性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sun Nov 11 00:59:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651424, encodeId=c8cd1651424db, content=<a href='/topic/show?id=3e8a653e2fe' target=_blank style='color:#2F92EE;'>#流行度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65372, encryptionId=3e8a653e2fe, topicName=流行度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acc724200297, createdName=piaojinhua, createdTime=Wed Sep 12 10:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329040, encodeId=96061329040a2, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348579, encodeId=b17f13485e93f, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405786, encodeId=4ac31405e868c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265763, encodeId=f1cf265e633f, content=非常实用.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Nov 30 21:20:20 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-12-02 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=2046910, encodeId=bffd204691001, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Oct 15 01:59:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027796, encodeId=0021202e796a4, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Thu Jan 04 03:59:00 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044933, encodeId=6eba20449330c, content=<a href='/topic/show?id=3dd62288e2b' target=_blank style='color:#2F92EE;'>#临床特性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22887, encryptionId=3dd62288e2b, topicName=临床特性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sun Nov 11 00:59:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651424, encodeId=c8cd1651424db, content=<a href='/topic/show?id=3e8a653e2fe' target=_blank style='color:#2F92EE;'>#流行度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65372, encryptionId=3e8a653e2fe, topicName=流行度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acc724200297, createdName=piaojinhua, createdTime=Wed Sep 12 10:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329040, encodeId=96061329040a2, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348579, encodeId=b17f13485e93f, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405786, encodeId=4ac31405e868c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265763, encodeId=f1cf265e633f, content=非常实用.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Nov 30 21:20:20 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2046910, encodeId=bffd204691001, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Oct 15 01:59:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027796, encodeId=0021202e796a4, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Thu Jan 04 03:59:00 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044933, encodeId=6eba20449330c, content=<a href='/topic/show?id=3dd62288e2b' target=_blank style='color:#2F92EE;'>#临床特性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22887, encryptionId=3dd62288e2b, topicName=临床特性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sun Nov 11 00:59:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651424, encodeId=c8cd1651424db, content=<a href='/topic/show?id=3e8a653e2fe' target=_blank style='color:#2F92EE;'>#流行度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65372, encryptionId=3e8a653e2fe, topicName=流行度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acc724200297, createdName=piaojinhua, createdTime=Wed Sep 12 10:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329040, encodeId=96061329040a2, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348579, encodeId=b17f13485e93f, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405786, encodeId=4ac31405e868c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265763, encodeId=f1cf265e633f, content=非常实用.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Nov 30 21:20:20 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-12-02 chg122
  8. [GetPortalCommentsPageByObjectIdResponse(id=2046910, encodeId=bffd204691001, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Oct 15 01:59:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027796, encodeId=0021202e796a4, content=<a href='/topic/show?id=72784e6449c' target=_blank style='color:#2F92EE;'>#局部过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47644, encryptionId=72784e6449c, topicName=局部过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Thu Jan 04 03:59:00 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044933, encodeId=6eba20449330c, content=<a href='/topic/show?id=3dd62288e2b' target=_blank style='color:#2F92EE;'>#临床特性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22887, encryptionId=3dd62288e2b, topicName=临床特性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sun Nov 11 00:59:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651424, encodeId=c8cd1651424db, content=<a href='/topic/show?id=3e8a653e2fe' target=_blank style='color:#2F92EE;'>#流行度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65372, encryptionId=3e8a653e2fe, topicName=流行度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acc724200297, createdName=piaojinhua, createdTime=Wed Sep 12 10:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329040, encodeId=96061329040a2, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348579, encodeId=b17f13485e93f, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405786, encodeId=4ac31405e868c, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Dec 02 11:59:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265763, encodeId=f1cf265e633f, content=非常实用.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Nov 30 21:20:20 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
    2017-11-30 swfzhanggui

    非常实用.感谢分享

    0

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