Nutr Metab Cardiovasc Dis:随着BMI增加,卒中发生风险增加

2018-08-19 国际循环编辑部 国际循环

发表于Nutrition,Metabolism and Cardiovascular Diseases的一项超过400万成人的荟萃分析显示,体质指数(BMI)与卒中事件风险存在J型关联。BMI每增加5个单位,卒中风险增加10%。

发表于Nutrition,Metabolism and Cardiovascular Diseases的一项超过400万成人的荟萃分析显示,体质指数(BMI)与卒中事件风险存在J型关联。BMI每增加5个单位,卒中风险增加10%。

大量证据表明,肥胖(根据BMI测定)是卒中的独立危险因素,但二者的剂量-反应关系究竟如何仍存在疑问。深圳大学医学部预防医学系胡东生教授等分析了2018年5月前发表的44项队列研究数据,评估了BMI与卒中风险之间的关系。研究共包括4 432 475例受试者中的102 466例卒中病例,如果研究根据至少三个BMI水平评估卒中风险升高,则被纳入分析。应用广义最小二乘回归法评估研究特异性剂量-反应系数,并研究了BMI与卒中类型之间的关系(出血性和缺血性)。

研究发现,BMI每增加5个单位,卒中发生的总体相对风险为1.1(95%CI:1.06~1.13),BMI与卒中风险之间存在J型相关。在BMI<24 kg/m2的成人受试者中,BMI与卒中风险无相关性,但对于BMI≥25 kg/m2者,卒中风险稳定增加。

根据卒中类型分层,缺血性卒中和出血性卒中发生的相对风险分别为1.2(95%CI:1.15~1.26)和0.99(95%CI:0.93~1.05)。在非线性、剂量反应分析中,研究人员发现,随着BMI的增加,缺血性卒中风险的增加与之存在非线性相关;但在出血性卒中的剂量-反应关系分析中,出血性卒中与BMI的增加呈U型相关,BMI为24 kg/m2时卒中风险最低(非线性P值<0.0001)。当按性别、地域、随访时间、病例数、研究质量分层,并校正年龄、吸烟状况、饮酒情况和教育等混杂因素后,结果仍然如此。

研究人员指出,分析只评估了BMI,并未评估脂肪分布,这意味着对于有重肌块者,所评估的卒中和肥胖之间的相关性可能并不正确。

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    2019-04-03 一闲
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    2018-11-11 guojianrong
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    2019-03-08 quxin068
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    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

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    2018-08-20 太阳系小猪

    为了减少卒中风险。也要减肥,减肥是健康需要

    0

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    2018-08-19 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2018-08-19 医者仁心5538

    有道理,控制体重很有必要

    0

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    2018-08-19 王秀

    学习了,涨知识了!

    0

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