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Cell Res：m6A RNA修饰在哺乳动物精子发生中的作用及其机制

2017-12-26 佚名 上海生科院

m6A精子机制
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Cell Research 在线发表了中国科学院上海生科院生物化学与细胞生物学研究所童明汉研究组的研究成果“Mettl3/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis”。该研究绘制了小鼠不同发育阶段生精细胞的m6A RNA修饰图谱，揭示了m6A RNA修饰通过调控精子发生过程中关键基因的转录后翻译

Cell Research 在线发表了中国科学院上海生科院生物化学与细胞生物学研究所童明汉研究组的研究成果“Mettl3/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis”。该研究绘制了小鼠不同发育阶段生精细胞的m6A RNA修饰图谱，揭示了m6A RNA修饰通过调控精子发生过程中关键基因的转录后翻译，从而控制精子发生的分子机制。

精子发生是一个高度复杂和特化的细胞发育过程，包括精原细胞增殖、精母细胞减数分裂和精子形成三个阶段。精子发生过程中的基因表达在转录水平、转录后水平及翻译水平上受到精密的调控，从而确保精子发生不同阶段功能特异基因的准确表达。例如，在长形精子阶段，细胞转录停止；其功能所需的mRNA在精母细胞或圆形精子阶段就已经转录生成，而一直处于翻译抑制状态，直到长形精子阶段再被翻译激活。因此，转录后调控及翻译调控在这一过程中发挥着尤为重要作用。 m6A RNA修饰是一种广泛而保守的表观遗传修饰，已有的体外研究表明m6A RNA修饰参与mRNA的降解、储存、可变剪接等多种转录后调控以及翻译调控。然而，对m6A RNA修饰是否以及如何在生理条件下调控哺乳动物器官发生和发育包括精子发生所知甚少。

应用m6A RNA甲基转移酶METTL3和／或METTL14的条件性基因敲除小鼠模型，在早期生精细胞（gonocyte)内，只要敲除METTL3或METTL14，均可导致精原干细胞丢失；在相对后期生精细胞(type A1spermatogonia)内，只有复合敲除METTL3和METTL14，才能够导致精子形成障碍。应用m6A-seq，研究人员绘制了精子发生不同发育阶段的生精细胞m6A RNA修饰动态变化图谱。结合该图谱，以及应用 RNA-Seq以及Ribosome profiling技术，研究发现失活m6A甲基转移酶后，其介导的m6A RNA修饰水平显着降低，导致调控精原干细胞命运决定和精子形成的相关基因转录后翻译效率显着变化。

该研究获中科院战略性先导科技专项B、国家科技部、国家自然科学基金委、上海生命科学研究院以及上海市科委经费资助。

原始出处：

Lin Z，et al.，Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.Cell Res. 2017 Oct；27(10)：1216-1230.

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    2018-08-25 柳叶一刀

    #m6A#

    0

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    2018-06-22 docwu2019

    #CEL#

    0

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    2018-09-13 zhaozhouchifen

    #Cell#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1647765, encodeId=f15b164e7657a, content=<a href='/topic/show?id=ac501119586' target=_blank style='color:#2F92EE;'>#m6A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11195, encryptionId=ac501119586, topicName=m6A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Aug 25 17:20:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960619, encodeId=68d51960619ea, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Jun 22 07:20:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870353, encodeId=4f1718e0353de, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Sep 13 16:20:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057468, encodeId=ace2205e46847, content=<a href='/topic/show?id=a7d3155507b' target=_blank style='color:#2F92EE;'>#RNA修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15550, encryptionId=a7d3155507b, topicName=RNA修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Feb 05 08:20:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278327, encodeId=60252e832704, content=今年国科金大热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Sun Jan 14 08:01:26 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514005, encodeId=3356151400549, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516752, encodeId=b1b01516e5251, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569302, encodeId=75291569302e6, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272685, encodeId=5e4c2e2685e9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Dec 26 14:31:42 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2018-02-05 drj2003

    #RNA修饰#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1647765, encodeId=f15b164e7657a, content=<a href='/topic/show?id=ac501119586' target=_blank style='color:#2F92EE;'>#m6A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11195, encryptionId=ac501119586, topicName=m6A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Aug 25 17:20:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960619, encodeId=68d51960619ea, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Jun 22 07:20:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870353, encodeId=4f1718e0353de, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Sep 13 16:20:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057468, encodeId=ace2205e46847, content=<a href='/topic/show?id=a7d3155507b' target=_blank style='color:#2F92EE;'>#RNA修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15550, encryptionId=a7d3155507b, topicName=RNA修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Feb 05 08:20:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278327, encodeId=60252e832704, content=今年国科金大热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Sun Jan 14 08:01:26 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514005, encodeId=3356151400549, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516752, encodeId=b1b01516e5251, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569302, encodeId=75291569302e6, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272685, encodeId=5e4c2e2685e9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Dec 26 14:31:42 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2018-01-14 kingjiang

    今年国科金大热点

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1647765, encodeId=f15b164e7657a, content=<a href='/topic/show?id=ac501119586' target=_blank style='color:#2F92EE;'>#m6A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11195, encryptionId=ac501119586, topicName=m6A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Aug 25 17:20:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960619, encodeId=68d51960619ea, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Jun 22 07:20:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870353, encodeId=4f1718e0353de, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Sep 13 16:20:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057468, encodeId=ace2205e46847, content=<a href='/topic/show?id=a7d3155507b' target=_blank style='color:#2F92EE;'>#RNA修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15550, encryptionId=a7d3155507b, topicName=RNA修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Feb 05 08:20:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278327, encodeId=60252e832704, content=今年国科金大热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Sun Jan 14 08:01:26 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514005, encodeId=3356151400549, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516752, encodeId=b1b01516e5251, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569302, encodeId=75291569302e6, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272685, encodeId=5e4c2e2685e9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Dec 26 14:31:42 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-28 ms1065684921169360

    #哺乳#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1647765, encodeId=f15b164e7657a, content=<a href='/topic/show?id=ac501119586' target=_blank style='color:#2F92EE;'>#m6A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11195, encryptionId=ac501119586, topicName=m6A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Aug 25 17:20:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960619, encodeId=68d51960619ea, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Jun 22 07:20:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870353, encodeId=4f1718e0353de, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Sep 13 16:20:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057468, encodeId=ace2205e46847, content=<a href='/topic/show?id=a7d3155507b' target=_blank style='color:#2F92EE;'>#RNA修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15550, encryptionId=a7d3155507b, topicName=RNA修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Mon Feb 05 08:20:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278327, encodeId=60252e832704, content=今年国科金大热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erJaiboOUVrGYoHV8Essd0EJvx0DPLDeqP3qkvaGD39DdvMmzT98iaib209rApLicEN84Nu8RefibOh8jA/132, createdBy=75ba1609552, createdName=kingjiang, createdTime=Sun Jan 14 08:01:26 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514005, encodeId=3356151400549, content=<a href='/topic/show?id=845339961b7' target=_blank style='color:#2F92EE;'>#哺乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39961, encryptionId=845339961b7, topicName=哺乳)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8fd10610597, createdName=ms1065684921169360, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516752, encodeId=b1b01516e5251, content=<a href='/topic/show?id=2ef539962d7' target=_blank style='color:#2F92EE;'>#哺乳动物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39962, encryptionId=2ef539962d7, topicName=哺乳动物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=762011007983, createdName=ms6279672939590805, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569302, encodeId=75291569302e6, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Thu Dec 28 05:20:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272685, encodeId=5e4c2e2685e9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Dec 26 14:31:42 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-28 ms6279672939590805

    #哺乳动物#

    0

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    2017-12-28 zhangyxzsh

    #修饰#

    0

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    2017-12-26 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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