Cardiovasc Diabetol:体重大幅度波动会增加2型糖尿病患者的心血管疾病风险!

2021-08-29 Nebula MedSci原创

高体重变异性可预测 2 型糖尿病患者心血管并发症的发生发展风险

糖尿病患者有较高的血管疾病发病率。据报道,体重变异性(BWV)是普通人群和 2 型糖尿病患者中心血管疾病(CVD)的独立危险因素

本研究使用瑞典国家糖尿病登记处的数据,在基线时未患心血管疾病的 2 型糖尿病患者中,评估了体重变异性与心血管并发症风险之间可能存在的相关性。共纳入了100576 名 2 型糖尿病患者,连续三年至少称了 5 次体重。变异性表示为三年内测量标准差的四分位数。主要复合终点包括非致命性心肌梗死、非致命性卒中和全因死亡率。

研究流程

BWV 上四分位数的患者更年轻,糖尿病病程更短,吸烟者患病率更高。体重随着 BWV 水平的增加而增加,而 HbA1c 则记录了相反的趋势。根据已知的心血管风险因素校正后,主要复合终点(非致命性心肌梗死、非致命性卒中和全因死亡率)的风险随着体重变异性的增加而显著升高,与最低(第4) BWV 四分位相比,最高、第2、第3 四分位的风险比(HR)分别是1.45(95%CI 1.39-1.52)、1.18(1.13-1.24)和1.08(1.03-1.13)。

各种心血管疾病的风险比

此外,体重指数变异性增加几乎与所有考虑到的其他心血管并发症均有关(非致命性心肌梗死、非致命性卒中、全因死亡率、外周动脉疾病、外周血管成形术、心力衰竭住院、足部溃疡和全因死亡率)。

综上所述,高体重变异性可预测 2 型糖尿病患者心血管并发症的发生发展风险。这些数据表明,任何降低这些受试者体重的策略都应同时注意长期保持体重的稳定降低,避免出现大幅度波动!

原始出处:

Ceriello, A., Lucisano, G., Prattichizzo, F. et al. Variability in body weight and the risk of cardiovascular complications in type 2 diabetes: results from the Swedish National Diabetes Register. Cardiovasc Diabetol 20, 173 (2021). https://doi.org/10.1186/s12933-021-01360-0

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    2022-09-05 小小医者

    #体重指数#变异性增加几乎与所有考虑到的其他#心血管#并发症均有关(非致命性心肌梗死、非致命性#卒中##全因死亡#率、#外周动脉疾病##外周血管成形术##心力衰竭#住院、足部溃疡和全因死亡率)。 综上所述,高#体重变异性#可预测 #2 型糖尿病#患者心血管并发症的发生发展风险。这些数据表明,任何降低这些受试者体重的策略都应同时注意长期保持体重的稳定降低,避免出现大幅度波动!

    0

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level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Mon Aug 30 12:39:24 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043766, encodeId=fc161043e6676, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 30 01:58:19 CST 2021, time=2021-08-30, status=1, ipAttribution=)]
    2022-04-03 quxin068
  3. 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04:58:19 CST 2022, time=2022-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639858, encodeId=76b61639858a1, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Oct 08 23:58:19 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383713, encodeId=35ee1383e13c6, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1243241, encodeId=f66c124324169, content=<a href='/topic/show?id=f96c266935c' target=_blank style='color:#2F92EE;'>#体重指数#</a>变异性增加几乎与所有考虑到的其他<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>并发症均有关(非致命性心肌梗死、非致命性<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>、<a href='/topic/show?id=27e6293315f' target=_blank style='color:#2F92EE;'>#全因死亡#</a>率、<a href='/topic/show?id=a98a42e977e' target=_blank style='color:#2F92EE;'>#外周动脉疾病#</a>、<a href='/topic/show?id=552710466e08' target=_blank style='color:#2F92EE;'>#外周血管成形术#</a>、<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>住院、足部溃疡和全因死亡率)。 综上所述,高<a href='/topic/show?id=17d1104668ed' target=_blank style='color:#2F92EE;'>#体重变异性#</a>可预测 <a href='/topic/show?id=a4331046697a' target=_blank style='color:#2F92EE;'>#2 型糖尿病#</a>患者心血管并发症的发生发展风险。这些数据表明,任何降低这些受试者体重的策略都应同时注意长期保持体重的稳定降低,避免出现大幅度波动!, beContent=null, 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level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Mon Aug 30 12:39:24 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043766, encodeId=fc161043e6676, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 30 01:58:19 CST 2021, time=2021-08-30, status=1, ipAttribution=)]
    2021-08-30 ms2000001361349190

    很棒

    0

  10. 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level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Mon Aug 30 12:39:24 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043766, encodeId=fc161043e6676, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Aug 30 01:58:19 CST 2021, time=2021-08-30, status=1, ipAttribution=)]
    2021-08-30 misszhang

    谢谢MedSci提供最新的资讯

    0

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J Periodontol:甲硝唑联合阿莫西林治疗伴2型糖尿病的牙周炎患者:一项随机对照试验随访 5 年的二次分析结果

已知糖尿病(DM)是牙周炎的危险因素,最近的系统回顾显示,在治疗牙周炎和2型糖尿病患者时,使用全身性抗生素作为洁治和根面平整术(SRP)的辅助治疗,比仅使用SRP的临床效益更佳。

Clin Nutr:脂类中奇链脂肪酸的含量与2型糖尿病风险的相关性

血浆奇链饱和脂肪酸(OCFA)与2型糖尿病(T2D)风险呈负相关

Medicina:褪黑素辅助全身应用可改善伴牙周病的2型糖尿病患者的血糖控制

有证据表明,褪黑激素可以改善糖尿病患者的牙周状况和血糖控制。近日,一项发表于Medicina的随机对照试验评估洗牙和根管治疗加上褪黑激素的辅助系统治疗对2型糖尿病和慢性牙周炎患者的牙周参数和血糖控制的

Lancet Diabetes Endocrinol:GLP-1受体激动剂可降低T2DM患者的多种心血管及肾脏不良事件的发生率

GLP-1受体激动剂可明显降低2型糖尿病患者的MACE、全因死亡、心衰住院和肾功能恶化的风险

Diabetes Obes Metab:利拉鲁肽可减少2型糖尿病患者心脏脂肪量

利拉鲁肽治疗26周后可减少心脏脂肪组织。心脏脂肪组织减少与体重减轻无关,表明这不是药物特异性作用。