Lancet Psychiatry:大麻使用与后继精神疾病风险

2019-03-24 MedSci MedSci原创

研究认为,使用频率和高效能大麻导致精神障碍发病率显著增加,高效能大麻供应的日益增加是公共卫生的严重威胁

大麻的使用可能与后继精神障碍的风险增加有关,近日研究人员对欧洲地区大麻使用与精神障碍发病率的相关性进行了考察。

18-64岁的首发精神病患者参与研究,以一般人群进行对照,采用逻辑回归模型估计大麻使用与精神失常的风险。研究人员考察参与者Δ9-四氢大麻酚(THC)浓度,将参与者使用的大麻分成两类:低效价(THC<10%)和高效力(THC<10%)。计算大麻使用与精神障碍的人群归因分数(PAFs)。

2010年5月1日至2015年4月1日,研究人员考察了901名首发精神病患者和1237名对照者数据。与从未使用大麻的人相比,每天使用大麻会增加患精神病的风险(HR=3.2),每天使用高效力大麻人群的风险增加到近五倍(HR=4.8)。PAFs计算结果表明,停止提供高效能大麻,可预防12.2%的首次发作精神病,伦敦地区的风险可降低30.3%,阿姆斯特丹为50.3%。调整后的精神病发生率与使用高效能大麻(r=0.7; p=0.0286)和日常使用(r=0.8; p=0.0109)呈正相关。

研究认为,使用频率和高效能大麻导致精神障碍发病率显著增加,高效能大麻供应的日益增加是公共卫生的严重威胁。

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    2019-10-17 howi
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    2019-03-26 kcb069
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