JCEM:褪黑素对肠促胰岛素的影响

2021-07-19 MedSci原创 MedSci原创

褪黑素减少了健康年轻男性口服葡萄糖期间GIP的分泌,但不影响胰岛素分泌。在大鼠肠道的原位模型中证实了GIP分泌减少。

葡萄糖稳态通过内分泌和细胞内机制受到了昼夜节律的调控,几项研究的证据表明褪黑激素影响了葡萄糖稳态。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估褪黑素对肠促胰岛素、高血糖素样肽1(GLP-1)和肠抑胃肽(GIP)分泌的影响,以及它们对β细胞胰岛素分泌的影响。


该研究是将一项人类随机、双盲、安慰剂对照的交叉研究与灌注大鼠肠道的验证性原位研究相结合。研究人员对15名健康男性参与者进行2x2次检查:在第一天进行口服葡萄糖耐量试验(OGTT),并在第二天进行重复的OGTT,并分别采用褪黑素和安慰剂治疗。对于原位研究,六个大鼠肠道和四个大鼠胰腺分别用灌注缓冲液±褪黑素进行动脉灌注。肠道同时通过腔室灌注葡萄糖。

使用褪黑激素治疗后OGTT检测的血糖水平


在人体试验中,与安慰剂相比,褪黑素治疗导致GIP分泌减少(ANOVA p=0.003),在灌注大鼠肠道中也观察到了这种效应(ANOVA p=0.003),其中GLP-1分泌也受到动脉灌注褪黑素的影响(ANOVA,p<0.001)。尽管GIP水平下降,体内葡萄糖刺激的胰岛素分泌不受褪黑素的影响(p=0.78)。
 
由此可见,褪黑素减少了健康年轻男性口服葡萄糖期间GIP的分泌,但不影响胰岛素分泌。在大鼠肠道的原位模型中证实了GIP分泌减少。

原始出处:

Esben Stistrup Lauritzen.et al.The effect of melatonin on incretin hormones – results from experimental and randomized clinical studies.JCEM.2021.https://doi.org/10.1210/clinem/dgab521

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    2022-10-11 lifestar
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    2022-01-20 achengzhao
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    2022-02-08 smallant2015
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    2022-07-03 baoya
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