Arthritis Rheumatol:吸烟和社会经济因素是否会影响中轴型脊柱关节炎的影像学结果?

2020-06-21 xiangting MedSci原创

蓝领或低学历axSpA患者中,基线吸烟与5年内每次访视时的MRI-SIJ炎症存在强相关性。这些发现表明,机械应力会增强吸烟对axSpA轴向炎症的作用。

这项研究旨在调查axSpA患者5年内吸烟与影像学结果之间的关系,并评估社会经济(SE)因素是否会影响这些关系。

纳入来自DESIR队列的axSpA患者。在基线、2年和5年时由三位中心阅片者评估4种影像学结果(脊柱X线片[改良的斯托克强直性脊柱炎脊柱评分,mSASSS];SIJ X线片[改良的纽约分级,mNY]);脊柱MRI[加拿大脊柱关节炎研究联盟评分,SPARCC]和MRI-SIJ [SPARCC])。感兴趣的解释变量是基线时的吸烟状况。首先检验了吸烟与SE因素(工作类型[蓝领vs白领]和受教育程度[低vs高])之间的相互作用,如果有显著性,则在不同的层次进行分析。使用了广义估计方程模型,并针对混杂因素进行了调整。

共纳入406名axSpA患者:男性占52%,吸烟者占40%和蓝领占18%。吸烟与5年内每次访视时MRI-SIJ的炎症较重独立相关,这种影响仅在蓝领(β[95%CI]:5.41[1.35,9.48])和受教育程度低(β[95%CI]:2.65[0.42,4.88]的患者中可见(单独模型)。在所有患者中,无论SE因素和其他潜在混杂因素如何,吸烟也与脊柱炎症(β[95%CI]:1.69[0.45,2.93])和SIJ损伤(β[95% CI]:0.57[0.18,0.96])显著相关。

研究发现蓝领或低学历axSpA患者中,基线吸烟与5年内每次访视时的MRI-SIJ炎症之间存在强相关性。这些发现表明,机械应力会增强吸烟对axSpA轴向炎症的作用。

原始出处:

Elena Nikiphorou. Do smoking and socioeconomic factors influence imaging outcomes in axial spondyloarthritis? Five‐year data from the DESIR cohort. Arthritis Rheumatol. 20 June 2020.

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    2020-06-23 lmm397
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    2020-06-23 zhaojie88
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