COVID-19疫苗BNT162b2进入II / III期临床研究

2020-08-03 Allan MedSci原创

辉瑞公司及其合作伙伴BioNTech近日表示,他们已决定将经过核苷修饰的mRNA疫苗候选产品BNT162b2推进到II / III期临床试验。

辉瑞公司及其合作伙伴BioNTech近日表示,他们已决定将经过核苷修饰的mRNA疫苗候选产品BNT162b2推进到II / III期临床试验。BNT162b1编码优化的SARS-CoV-2受体结合域(RBD)抗原。预计该试验将招募30,000名18至85岁之间的参与者,这些参与者将被随机分配接受BNT162b2或安慰剂治疗,研究地点遍布美国以及阿根廷、巴西和德国等国家。

BNT162b2是BNT162 mRNA的疫苗计划的一部分。本月初,辉瑞公司和BioNTech公司宣布了来自美国和德国的一项正在进行的I / II期研究的结果,该研究表明BNT162b1能够激发健康志愿者的抗SARS-CoV-2免疫力。BNT162b2诱导了“高强度” CD4 +和CD8 + T细胞反应。

两家公司表示:“基于我们临床前和临床研究的全部可用数据,包括免疫应答和耐受性参数,BNT162b2可以作为主要候选疫苗”。

 

原始出处:

https://www.firstwordpharma.com/node/1744022?tsid=4

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    2021-05-12 juliusluan78
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