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IEEE Trans Nanobioscience：在单壁碳纳米管存在下增强人间充质干细胞的成骨作用

2019-05-26 不详 网络

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人间充质干细胞（hMSCs）因其分化为骨细胞，软骨细胞，脂肪细胞和肌肉细胞的能力而引起了组织工程的重视。 单壁碳纳米管（SWCNT）由于其独特的性质如高纵横比，优异的电催化活性和生物相容性而被认为是组织工程应用的潜在材料。在这里，我们通过在酸性介质中的超声处理过程制备剥离的SWCNTs层，并使用hMSC评估它们的细胞毒性。 在剥脱的SWCNT存在下观察到hMSC的活力和骨生成的改善。此外，在脱落的

人间充质干细胞（hMSCs）因其分化为骨细胞，软骨细胞，脂肪细胞和肌肉细胞的能力而引起了组织工程的重视。

单壁碳纳米管（SWCNT）由于其独特的性质如高纵横比，优异的电催化活性和生物相容性而被认为是组织工程应用的潜在材料。在这里，我们通过在酸性介质中的超声处理过程制备剥离的SWCNTs层，并使用hMSC评估它们的细胞毒性。 在剥脱的SWCNT存在下观察到hMSC的活力和骨生成的改善。此外，在脱落的SWCNT存在下，成骨分化相关基因的更高表达进一步证实了它们增强的成骨性质。

综上所述，这些结果表明SWCNT作为组织工程应用的生物材料的潜力。

原始出处：

Kim HB, Jin B, et al., Enhanced osteogenesis of human mesenchymal stem cells in presence of single-walled carbon nanotubes. IEEE Trans Nanobioscience. 2019 May 2. doi: 10.1109/TNB.2019.2914127. 

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    2019-10-23 bsmagic9140

    #TRA#

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    2019-10-16 sunylz

    #Bio#

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    2019-08-07 h.y200607_23674418

    #间充质干细#

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    2019-05-28 zhaojie88

    #成骨#

    0

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    2019-05-28 智智灵药

    #SCIE#

    0