JASN:皮肤钠浓度与CKD患者左心室肥厚

2017-02-22 xing.T MedSci原创

总之,该研究发现皮肤的钠含量与CKD患者左心室重量密切相关。减少皮肤钠含量的干预措施可能改善这些患者的心血管预后。

慢性肾脏病患者左心室肥厚的发病机制尚不完全清楚。钠的摄入,通常是通过测定尿钠排泄量来进行评估,其结果已不完全与左心室肥厚相一致。然而,像皮肤和肌肉这样的组织也可以储存钠离子。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology发表一篇相关的研究文章。

使用23钠磁共振成像,该技术是近几年发展起来的用于人类组织钠含量的评估,研究人员测定了99例轻度到中度CKD患者(女性为42例;平均年龄[范围]65岁[23-78岁])小腿平面皮肤中的钠含量。研究人员还评估了体内水分过多总量(生物电阻抗谱)、24小时血压以及左心室重量(心脏磁共振成像)。

皮肤的钠含量,而不是体内水分过多总量,与收缩压呈正相关(r=0.33,P=0.002)。皮肤的钠含量与体内水分过多总量和左心室重量密切相关(r=0.56,P<0.001 vs. r=0.35,P<0.001;两种相关性之间P<0.01)。线性回归分析表明,皮肤的钠含量是左心室重量一个很强的解释变量,并不受血压和体内水分过多总量的影响。

总之,该研究发现皮肤的钠含量与CKD患者左心室重量密切相关。减少皮肤钠含量的干预措施可能改善这些患者的心血管预后。

原始出处:


Markus P. Schneider,et al. Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD. JASN, 2017,doi:10.1681/ASN.2016060662


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    2017-11-11 chenhongpeng
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    2017-02-23 1ddf0692m34(暂无匿称)

    创新性强

    0

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    2017-02-23 1e10c84am36(暂无匿称)

    文章很不错哦

    0