Radiology:非增强CT检查自动肝脂肪定量的应用价值

2019-12-12 shaosais MedSci原创

背景:非酒精性脂肪肝及其并发症越来越受到公众健康的关注,对于脂肪肝的非侵入性诊断和定量评估是非常有价值的。本研究旨在评估基于深度学习的自动肝脂肪体积定量方法来评估脂肪肝的发生率。

背景:非酒精性脂肪肝及其并发症越来越受到公众健康的关注,对于脂肪肝的非侵入性诊断和定量评估是非常有价值的。本研究旨在评估基于深度学习的自动肝脂肪体积定量方法来评估脂肪肝的发生率。

本研究应用3D卷积神经网络联合全自动肝脏分割算法对无症状成年患者的腹部CT平扫进行分析,并对亚组进行随访。分析基于体积肝脏密度,包括CT脂肪分数转换,并与人工勾画结果进行比较。

结果为,本研究共纳入了9552例患者的11669次CT扫描,其中对1862例患者随访共计2117次。算法失败主要发生了7次CT检查图像中。平均肝脏CT值为55 HU ± 10,相关CT脂肪分数为6.4%(男性要比女性脂肪含量要高一些[7.4% ± 6.0 vs 5.8% ± 5.7%; P < .001])。不同年龄下平均肝脏CT值变化很小(<4HU),且与BMI有微弱相关性(r2 = 0.14)。根据分类,47.9% (5584 / 11 669)无或具有轻微脂肪肝 (CT 为 <5%), 42.4% (4948 / 11 669) 具有轻度脂肪肝(CT 为 /5%-14%), 8.8% (1025 / 11 669)具有中度脂肪肝 (CT 为 /14%-28%), and 1% (112 / 11 669)具有重度脂肪肝 (CT 为 >28%)。全自动算法和人工勾画结果具有很好一致性,两者差异约为2.7HU(r2 为0.92)。在亚组纵向分析中,平均变化仅为-3 HU ± 9,然而有43.3% (806 /1861)的患者在首次和最后一次检查中脂肪肝分类发生变化。

本研究表明,基于CT全自动脂肪肝定量方法能够对肝脂肪变性和非酒精性脂肪肝进行评价,所得结果与人工测算具有良好一致性。在非症状性大规模筛查中轻度以上脂肪肝的发生率超过50%。

原始出处:

Graffy PM, Sandfort V, Summers RM,et al.Automated Liver Fat Quantification at Nonenhanced Abdominal CT for Population-based Steatosis Assessment.Radiology.DOI:10.1148/radiol.2019190512

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2034719, encodeId=f4de2034e1922, content=<a href='/topic/show?id=79d099360d2' target=_blank style='color:#2F92EE;'>#非增强#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99360, encryptionId=79d099360d2, topicName=非增强)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Mon Mar 09 15:00:00 CST 2020, time=2020-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987060, encodeId=0576198e06042, content=<a href='/topic/show?id=a498422e7e6' target=_blank style='color:#2F92EE;'>#增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42277, encryptionId=a498422e7e6, topicName=增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Jun 30 10:00:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454949, encodeId=05b0145494991, content=<a href='/topic/show?id=697c5465d9' target=_blank style='color:#2F92EE;'>#CT检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5465, encryptionId=697c5465d9, topicName=CT检查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07e5619265, createdName=kzlchina, createdTime=Sat Dec 14 00:00:00 CST 2019, time=2019-12-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2034719, encodeId=f4de2034e1922, content=<a href='/topic/show?id=79d099360d2' target=_blank style='color:#2F92EE;'>#非增强#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99360, encryptionId=79d099360d2, topicName=非增强)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Mon Mar 09 15:00:00 CST 2020, time=2020-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987060, encodeId=0576198e06042, content=<a href='/topic/show?id=a498422e7e6' target=_blank style='color:#2F92EE;'>#增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42277, encryptionId=a498422e7e6, topicName=增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Jun 30 10:00:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454949, encodeId=05b0145494991, content=<a href='/topic/show?id=697c5465d9' target=_blank style='color:#2F92EE;'>#CT检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5465, encryptionId=697c5465d9, topicName=CT检查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07e5619265, createdName=kzlchina, createdTime=Sat Dec 14 00:00:00 CST 2019, time=2019-12-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2034719, encodeId=f4de2034e1922, content=<a href='/topic/show?id=79d099360d2' target=_blank style='color:#2F92EE;'>#非增强#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99360, encryptionId=79d099360d2, topicName=非增强)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Mon Mar 09 15:00:00 CST 2020, time=2020-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987060, encodeId=0576198e06042, content=<a href='/topic/show?id=a498422e7e6' target=_blank style='color:#2F92EE;'>#增强CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42277, encryptionId=a498422e7e6, topicName=增强CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Jun 30 10:00:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454949, encodeId=05b0145494991, content=<a href='/topic/show?id=697c5465d9' target=_blank style='color:#2F92EE;'>#CT检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5465, encryptionId=697c5465d9, topicName=CT检查)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07e5619265, createdName=kzlchina, createdTime=Sat Dec 14 00:00:00 CST 2019, time=2019-12-14, status=1, ipAttribution=)]
    2019-12-14 kzlchina