Clin Gastroenterology H:无症状青年结直肠肿瘤的患病率和危险因素分析

2019-01-11 MedSci MedSci原创

50岁以下的人群中结肠直肠癌的发病率正在逐年增加。然而,有关年轻发病性结直肠肿瘤(CRN)流行病学的数据很有限。虽然一些研究调查了CRN在50岁以下人群中的流行病学数据,但大多数研究都集中在40岁或以上的人群。因此,本项研究旨在评估40岁以下成人CRN的患病率和危险因素。

背景与目的
50岁以下的人群中结肠直肠癌的发病率正在逐年增加。然而,有关年轻发病性结直肠肿瘤(CRN)流行病学的数据很有限。虽然一些研究调查了CRN在50岁以下人群中的流行病学数据,但大多数研究都集中在40岁或以上的人群。因此,本项研究旨在评估40岁以下成人CRN的患病率和危险因素。

方法
研究人员对2004年8月至2015年12月期间接受结肠镜检查的72356名无症状个体进行了横断面分析。有关病史和健康相关行为的数据是从问卷中收集。研究人员将患者分为20-29岁组,N = 7340和30-39岁组,N = 65016),多变量逻辑回归模型用于评估整体和晚期CRN的风险因素。

结果
20-29岁组CRN总体患病率为5.9%,30-39岁组CRN患病率为9.5%(P <.001); 晚期CRN的患病率分别为0.6%和0.9%(P = .005)。在30-39岁年龄组中,年龄,吸烟,饮酒,肥胖和腹部肥胖是整体和晚期CRN的独立危险因素。此外,男性和代谢综合征是整体CRN的独立危险因素,而定期运动可降低整体CRN的风险。即使在20-29岁年龄组中,肥胖,腹部肥胖和甘油三酯水平升高是整体和晚期CRN的独立危险因素,而年龄,血压升高和空腹血糖水平升高是整体CRN的独立危险因素。

结论
在本项回顾性研究中研究人员发现吸烟,饮酒,肥胖和代谢综合征,是CRN的重要危险因素。

原始出处:

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    2019-09-24 许安
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